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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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The spectrum of spinal cord lesions in a primate model of multiple sclerosis

Jennifer A Lefeuvre1, Joseph R Guy2, Nicholas J Luciano2

  • 1Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA/Institut du Cerveau et de la Moelle-ICM, Centre de NeuroImagerie de Recherche-CENIR, Sorbonne Universités, Paris, France.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|February 8, 2019
PubMed
Abstract

Insights

Experimental autoimmune encephalomyelitis (EAE) in marmosets reveals spinal cord damage similar to multiple sclerosis (MS). High-resolution MRI and histopathology confirmed demyelination and inflammation in EAE lesions, advancing MS research.

Area of Science:

  • Neuroscience
  • Immunology
  • Primate Models

Background:

  • Experimental autoimmune encephalomyelitis (EAE) in common marmosets serves as a nonhuman primate model for multiple sclerosis (MS).
  • EAE in marmosets exhibits clinical, radiological, and pathological features mirroring human MS, including motor and sensory deficits indicative of spinal cord damage.

Purpose of the Study:

  • To precisely characterize the extent and nature of spinal cord (SC) damage in marmosets with EAE.
  • To integrate magnetic resonance imaging (MRI) and histopathology for a comprehensive analysis of SC lesions.

Main Methods:

  • High-resolution 7 Tesla (7T) ex vivo MRI scans of SC tissues from five marmosets with EAE.
  • Segmentation and classification of SC lesions based on morphology and distribution.
  • Histopathological analysis of myelin and microglia/macrophages, correlated with MRI findings using linear mixed-effects models.

Main Results:

  • Two distinct SC lesion types were identified: focal and subpial.
  • Lesions were heterogeneous, characterized by significant demyelination and inflammatory cell infiltration.
  • A strong positive correlation was observed between MRI signal intensity and myelin content within lesions (p < 0.001).

Conclusions:

  • The marmoset EAE model effectively recapitulates key aspects of MS SC pathology.
  • This model is highly relevant for investigating the mechanisms underlying MS lesion formation in the spinal cord.
Keywords:
EAEMRIMultiple sclerosismarmosetspinal cord

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