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Application of Vancomycin Powder to Reduce Surgical Infection and Deep Surgical Infection in Spinal Surgery: A

Xiaoqi He1,2, Tianwei Sun2, Jizhou Wang2

  • 1Graduate School of Tianjin Medical University.

Clinical Spine Surgery
|February 8, 2019
PubMed
Abstract

Insights

Vancomycin powder significantly reduces surgical site infections (SSI) and deep SSI in spinal surgery. It is particularly beneficial for instrumented spinal procedures, offering a valuable adjunctive therapy.

Area of Science:

  • Orthopedic Surgery
  • Infectious Disease Prevention
  • Pharmacology

Background:

  • Surgical site infection (SSI) is a significant complication following spinal surgery.
  • Local vancomycin powder application is explored as an adjunctive method to mitigate SSI risk.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the efficacy of vancomycin powder in reducing SSI in spinal surgery.
  • To assess the impact of vancomycin powder on both superficial and deep SSI.

Main Methods:

  • A systematic literature search was performed across multiple databases (PubMed, Scopus, etc.).
  • A fixed-effects model was employed to calculate pooled relative risks and 95% confidence intervals (CI).
  • Heterogeneity was assessed using I statistics, and subgroup analyses were conducted.

Main Results:

  • The meta-analysis included 21 studies, demonstrating a significant reduction in SSI (RR 0.36, P=0.000) and deep SSI (RR 0.28, P=0.000) with vancomycin powder.
  • Subgroup analysis indicated a particular benefit in instrumented spinal surgery.
  • No significant association was found between vancomycin powder and pseudoarthrosis (RR 0.88, P=0.784).

Conclusions:

  • Vancomycin powder effectively decreases the incidence of SSI and deep SSI in spinal surgery.
  • The agent shows particular benefit in instrumented procedures.
  • Further research is needed to definitively assess any potential link to pseudoarthrosis.

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