Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structural Steel Products01:24

Structural Steel Products

677
Structural steel products are created within a structural mill. The process begins with a beam blank that is reheated and then fed through a series of rollers. These rollers progressively shape the metal into its final form. Adjusting the spacings between the rollers allows for the production of different sections with the same nominal dimensions.
Once shaped, the steel's final form emerges as a continuous length, which is then segmented by a hot saw into manageable pieces. These segments...
677
Simplification of a Force and Couple System I01:18

Simplification of a Force and Couple System I

943
The concept of reducing a system of forces and couple moments to an equivalent system is essential in simplifying the analysis of rigid bodies. This reduction allows for more straightforward computation and understanding of the external effects produced by the system. In particular, systems with an equivalent resultant force and a resultant couple moment having perpendicular lines of action can be further reduced to a single equivalent resultant force acting along a new line of action. There...
943
Simplification of a Force and Couple System: II01:23

Simplification of a Force and Couple System: II

609
In a three-dimensional system, multiple forces can act on an object. These forces can be combined into a single equivalent force, known as the resultant force. Similarly, the moments generated by these forces can be combined into a single equivalent moment, the resultant couple moment. In certain situations, these two entities may not be mutually perpendicular, meaning they do not have a 90-degree angle between them. This unique condition requires a deeper understanding of the interplay between...
609
What is Natural Selection?01:32

What is Natural Selection?

128.8K
Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
128.8K
Nature and Nurture01:10

Nature and Nurture

22.3K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
22.3K
The Wave Nature of Light02:12

The Wave Nature of Light

61.3K
The nature of light has been a subject of inquiry since antiquity. In the seventeenth century, Isaac Newton performed experiments with lenses and prisms and was able to demonstrate that white light consists of the individual colors of the rainbow combined together. Newton explained his optics findings in terms of a "corpuscular" view of light, in which light was composed of streams of extremely tiny particles traveling at high speeds according to Newton's laws of motion.
61.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery of a Potent NAMPT-Targeting PROTAC for the Suppression of Triple-Negative Breast Cancer via Macrophage Reprogramming.

Journal of medicinal chemistry·2026
Same author

GID4-Recruiting PROTACs for BRD4 Degradation Overcome Resistance Driven by CRBN and VHL Deficiency.

Journal of medicinal chemistry·2026
Same author

Discovery of Novel Hsp90 Inhibitor-Evodiamine Derivative Conjugates as Potent and Orally Active Antitumor Agents for Colon Cancer Therapy.

Journal of medicinal chemistry·2026
Same author

Exosome-Coated Boron-Containing Evodiamine Derivative Triggered by Pathology-Specific Reactive Oxygen Species Targets Myofibroblasts to Ameliorate Hypertrophic Scarring.

ACS applied materials & interfaces·2026
Same author

Modified Management of Giant Hiatal Hernia: Laparoscopic Hiatoplasty With Sac Excision and Posterior Mediastinal Drainage.

Surgical laparoscopy, endoscopy & percutaneous techniques·2026
Same author

Discovery of New Pyrazolone Derivatives for Treating Invasive Fungal Infections by Iron Homeostasis Disruption.

Journal of medicinal chemistry·2026

Related Experiment Video

Updated: Jan 29, 2026

Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products
11:13

Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products

Published on: March 12, 2020

11.6K

Structural Simplification of Natural Products.

Shengzheng Wang1,2, Guoqiang Dong1, Chunquan Sheng1

  • 1Department of Medicinal Chemistry, School of Pharmacy , Second Military Medical University , 325 Guohe Road , Shanghai , 200433 , P.R. China.

Chemical Reviews
|February 8, 2019
PubMed
Summary
This summary is machine-generated.

Structural simplification of natural products (NPs) addresses challenges like synthetic difficulty and poor drug-likeness. This review explores strategies and successful case studies for developing improved NP-based drugs.

More Related Videos

Generation of Monoclonal Antibodies Against Natural Products
12:15

Generation of Monoclonal Antibodies Against Natural Products

Published on: April 6, 2019

11.6K
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
07:59

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

10.4K

Related Experiment Videos

Last Updated: Jan 29, 2026

Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products
11:13

Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products

Published on: March 12, 2020

11.6K
Generation of Monoclonal Antibodies Against Natural Products
12:15

Generation of Monoclonal Antibodies Against Natural Products

Published on: April 6, 2019

11.6K
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
07:59

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

10.4K

Area of Science:

  • Medicinal Chemistry
  • Drug Discovery
  • Natural Products Chemistry

Background:

  • Natural products (NPs) offer diverse structures and biological prevalidation for drug development.
  • However, NP complexity causes synthetic challenges, poor pharmacokinetics, and reduced drug-likeness.
  • Structural simplification is a key strategy to overcome these limitations.

Purpose of the Study:

  • To review structural simplification strategies for natural products.
  • To highlight case studies of successful NP simplification in drug development.
  • To discuss emerging technologies in NP structural modification.

Main Methods:

  • Literature review of structural simplification in natural product drug discovery.
  • Analysis of design strategies, including truncation of substructures.
  • Examination of case studies of marketed drugs and clinical candidates derived from NPs.

Main Results:

  • Structural simplification effectively improves synthetic accessibility and pharmacokinetic profiles of NPs.
  • Numerous examples demonstrate successful lead optimization through NP truncation.
  • Key design principles and technological advancements facilitate NP simplification.

Conclusions:

  • Structural simplification is a vital approach for efficient natural product-based drug development.
  • This strategy enhances the drug-likeness and clinical viability of NP-derived compounds.
  • Further exploration of simplification techniques will accelerate the discovery of novel therapeutics.