Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

4.1K
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
4.1K
What is Homeostasis?01:16

What is Homeostasis?

54.3K
Maintaining homeostasis requires that the body continuously maintain its internal conditions. Each physiological condition has a particular set point, from body temperature to blood pressure to levels of certain nutrients. A set point is the physiological value around which the normal range fluctuates. A normal range is a restricted set of values that is optimally healthful and stable. For example, the set point for normal human body temperature is approximately 37°C (98.6°F).
54.3K
pH Homeostasis01:31

pH Homeostasis

18.6K
Acid-base homeostasis is essential for maintaining normal physiological activities in humans. The pH of various body fluids is strictly regulated because it is critical for the optimal activity of enzymes involved in metabolic reactions. Enzymes are basically proteins, so, any significant change in pH can affect their structure and activity. In humans, pH is regulated using three primary mechanisms— chemical buffer systems, respiratory regulation, and renal regulation.
Respiratory...
18.6K
Classification of Skeletal Muscle Fibers01:48

Classification of Skeletal Muscle Fibers

59.5K
Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
59.5K
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

5.9K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
5.9K
Anatomy of the Intestines01:23

Anatomy of the Intestines

87.3K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
87.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Baseline serum metabolites predict fractures in individuals who were Black and had type 2 diabetes.

Frontiers in endocrinology·2026
Same author

The periosteum as an endocrine organ: historical foundations and new insights.

Open biology·2026
Same author

Bone as an endocrine regulator of lipid and energy metabolism.

Reviews in endocrine & metabolic disorders·2026
Same author

11β-Hydroxysteroid dehydrogenase type 1 deficiency causes sexual dimorphism in body composition and bone mass in response to caloric restriction.

JBMR plus·2026
Same author

Neuroendocrine and neural control of bone mass in health and disease.

The Journal of clinical investigation·2026
Same author

Intact mTOR signaling in gastric X/A-like cells is required for bone homeostasis.

Frontiers in endocrinology·2026

Related Experiment Video

Updated: Jan 29, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

15.8K

Intestinal clock system regulates skeletal homeostasis.

Masanobu Kawai1, Saori Kinoshita1, Miwa Yamazaki1

  • 1Department of Bone and Mineral Research, Research Institute, Osaka Women's and Children's Hospital, Izumi, Osaka, Japan.

JCI Insight
|February 8, 2019
PubMed
Summary
This summary is machine-generated.

The intestinal circadian clock regulates bone health. Loss of the Bmal1 gene in the gut disrupts calcium absorption and bone metabolism, leading to bone loss.

Keywords:
Bone BiologyCalciumGastroenterology

More Related Videos

Clock Scan Protocol for Image Analysis: ImageJ Plugins
07:19

Clock Scan Protocol for Image Analysis: ImageJ Plugins

Published on: June 19, 2017

18.0K
Monitoring Endoplasmic Reticulum Calcium Homeostasis Using a Gaussia Luciferase SERCaMP
08:41

Monitoring Endoplasmic Reticulum Calcium Homeostasis Using a Gaussia Luciferase SERCaMP

Published on: September 6, 2015

13.8K

Related Experiment Videos

Last Updated: Jan 29, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

15.8K
Clock Scan Protocol for Image Analysis: ImageJ Plugins
07:19

Clock Scan Protocol for Image Analysis: ImageJ Plugins

Published on: June 19, 2017

18.0K
Monitoring Endoplasmic Reticulum Calcium Homeostasis Using a Gaussia Luciferase SERCaMP
08:41

Monitoring Endoplasmic Reticulum Calcium Homeostasis Using a Gaussia Luciferase SERCaMP

Published on: September 6, 2015

13.8K

Area of Science:

  • Endocrinology
  • Bone Biology
  • Chronobiology

Background:

  • The circadian clock regulates metabolic homeostasis, but its role in skeletal metabolism is unclear.
  • The Bmal1 gene is crucial for circadian rhythms and metabolic regulation.

Purpose of the Study:

  • To investigate the role of the intestinal circadian clock in regulating skeletal metabolism.
  • To elucidate the molecular mechanisms linking intestinal circadian rhythms to bone homeostasis.

Main Methods:

  • Utilized Bmal1Int-/- mice lacking the Bmal1 gene specifically in the intestines.
  • Analyzed bone resorption and formation markers.
  • Investigated Clock protein interaction with the vitamin D receptor (VDR).
  • Assessed transcellular calcium absorption and sympathetic tone.

Main Results:

  • Bmal1Int-/- mice exhibited bone loss due to increased bone resorption and decreased bone formation.
  • Loss of Bmal1 disrupted the circadian regulation of VDR target genes and impaired calcium absorption.
  • Elevated sympathetic tone in Bmal1Int-/- mice contributed to bone loss, which was partially reversed by blockade.

Conclusions:

  • The intestinal circadian clock network is essential for maintaining skeletal homeostasis.
  • Intestinal circadian rhythms regulate bone metabolism through VDR-mediated calcium absorption and modulation of sympathetic tone.