Related Experiment Videos
Effects of Species-Specific Genetics on Alzheimer's Mouse Models
Bradley Hyman1, Rudolph E Tanzi1
1Massachusetts General Hospital and Harvard Medical School, 114 16(th) Street, Charlestown, MA 02129, USA.
Neuron
|February 8, 2019
Abstract:
In this issue of Neuron, Neuner et al. (2019) report the generation of Alzheimer's disease (AD) transgenic mouse models on a panel of 28 background strains, showing marked background-dependent phenotypic variability. These findings imply that analogous variation in human AD phenotypes may be due, at least in part, to subtle effects of genetic background.