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Related Concept Videos

Phosphate Buffer01:22

Phosphate Buffer

5.1K
The phosphate buffer system is a critical biological mechanism for maintaining pH stability in the body. This system operates primarily through two components: sodium dihydrogen phosphate (NaH2PO4), which acts as a weak acid, and sodium hydrogen phosphate (Na2HPO4), which serves as a weak base.
Sodium dihydrogen phosphate does not fully dissociate in neutral or acidic solutions. When a strong base, such as sodium hydroxide (NaOH), is introduced into the solution, sodium dihydrogen phosphate...
5.1K
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

5.6K
Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
5.6K
The Equilibrium Binding Constant and Binding Strength02:18

The Equilibrium Binding Constant and Binding Strength

15.0K
The equilibrium binding constant (Kb) quantifies the strength of a protein-ligand interaction. Kb can be calculated as follows when the reaction is at equilibrium:
15.0K
The Equilibrium Binding Constant and Binding Strength02:18

The Equilibrium Binding Constant and Binding Strength

10.0K
10.0K
Roles of Electrolytes: Calcium and Phosphate01:27

Roles of Electrolytes: Calcium and Phosphate

1.2K
Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily...
1.2K
Ligand Binding Sites02:40

Ligand Binding Sites

15.0K
Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
15.0K

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Ferric Chloride-induced Murine Thrombosis Models
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Ferric Chloride-induced Murine Thrombosis Models

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Ferric citrate: a novel phosphate-binding agent.

Kausik Umanath1, Robert Niecestro2, Julia B Lewis3

  • 1a Division of Nephrology and Hypertension, Henry Ford Hospital, Detroit, MI, USA.

Expert Review of Endocrinology & Metabolism
|February 9, 2019
PubMed
Summary
This summary is machine-generated.

Ferric citrate is a new medication that effectively lowers phosphate levels in dialysis patients. It is safe and well-tolerated, offering potential benefits for iron and citrate absorption in end-stage renal disease.

Keywords:
CKD-MBDESRDiron metabolismmetabolic acidosisphosphate binder

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Area of Science:

  • Nephrology
  • Pharmacology

Background:

  • Hyperphosphatemia is a common complication in patients with end-stage renal disease (ESRD).
  • Elevated phosphate levels contribute to significant morbidity and mortality in ESRD patients.
  • Current phosphate binders have limitations, necessitating novel therapeutic options.

Purpose of the Study:

  • To evaluate the efficacy and safety of ferric citrate as a phosphate binder in dialysis patients.
  • To assess the potential benefits of ferric iron and citrate absorption from ferric citrate in ESRD.

Main Methods:

  • Ferric citrate is a novel agent that binds dietary phosphorus in the gastrointestinal tract.
  • The bound phosphorus is then eliminated via stool.
  • Ongoing Phase III clinical trials are confirming its safety and efficacy profile.

Main Results:

  • Previous studies indicate ferric citrate is efficacious in lowering phosphate levels.
  • The agent has demonstrated a favorable safety profile with predominantly mild gastrointestinal side effects.
  • Potential for beneficial absorption of ferric iron and citrate in ESRD patients.

Conclusions:

  • Ferric citrate is a promising novel phosphate binder for managing hyperphosphatemia in dialysis patients.
  • Its safety and efficacy are being further confirmed in ongoing Phase III trials.
  • Potential dual benefit of phosphate binding and nutrient absorption makes it a valuable therapeutic option.