Stereotactic CT localization and biopsy of brain tumours using the Leksell frame. A study of 45 cases

The authors have explored 45 patients presenting with clinical and CT evidence of space-occupying process in the brain. They endeavoured to determine the nature of the processes by performing stereotactic biopsy after localization by CT in 43 cases, by magnetic resonance imaging in 2 cases and by angiography in 1 case. The method proved reliable: the quality of the biopsy specimens obtained enabled the pathologist to make a satisfactory diagnosis by light microscopy after freezing in almost every case. Moreover, the orifice of penetration of the Leksell-Sedan needle provided a very accurate localization of the lesion when surgery was needed. Several specimens were taken during each session, since histological findings may vary according to the site of biopsy. All explorations were carried out under local anaesthesia. Two cases of haemorrhage were recorded; they were without long-term consequences but required surgery.