Related Experiment Video

Updated: Jan 29, 2026

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
09:36

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Published on: October 16, 2010

30.2K

Risk prediction for breast Cancer in Han Chinese women based on a cause-specific Hazard model

Lu Wang1, Liyuan Liu2,3, Zhen Lou4

  • 1Department of Biostatistics, School of Public Health, Shandong University, 44 Wen Hua Xi Road, Jinan, 250012, China.

BMC Cancer
|February 9, 2019
PubMed

Insights

A new breast cancer risk prediction model was developed for Han Chinese women, identifying high-risk individuals for targeted prevention. Key factors include fertility history, benign breast disease, and body mass index (BMI).

Area of Science:

  • Oncology
  • Epidemiology
  • Biostatistics

Background:

  • Lack of efficient breast cancer prediction models for general population screening in China.
  • Need for targeted primary prevention strategies for breast cancer among Han Chinese women.

Purpose of the Study:

  • To develop and validate a breast cancer risk prediction model for Han Chinese women.
  • To identify high-risk populations for enhanced breast cancer screening and prevention.

Main Methods:

  • Utilized a cause-specific competing risk model for model development.
  • Employed data from the Shandong Case-Control Study and Taixing Prospective Cohort Study for development and validation.
  • Evaluated model calibration and discriminative accuracy using expected/observed (E/O) ratio and C-statistic.

Main Results:

  • Identified significant risk factors: number of abortions (RR=6.3), age at first live birth (RR=3.6), history of benign breast disease (RR=4.3), body mass index (BMI) (RR=1.9), family history of breast cancer (RR=3.3), and life satisfaction scores (RR=2.4).
  • The developed model demonstrated good calibration (E/O ratio=1.03) and discriminatory accuracy (C-statistic=0.64).

Conclusions:

  • A novel risk prediction model for breast cancer was successfully developed for the Han Chinese population.
  • The model incorporates fertility status, disease history, and modifiable risk factors.
  • The model exhibits satisfactory calibration and discrimination, suitable for clinical application in risk assessment.
Abstract

Keywords:
Breast neoplasmsPopulation at riskRisk assessment

More Related Videos

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

906
X-ray Visualization of Intraductal Ethanol-based Ablative Infusion for Prevention of Breast Cancer in Rabbit Models08:16

X-ray Visualization of Intraductal Ethanol-based Ablative Infusion for Prevention of Breast Cancer in Rabbit Models

Published on: September 12, 2025

862

Related Concept Videos

Sensitivity, Specificity, and Predicted Value01:13

Sensitivity, Specificity, and Predicted Value

In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
Sensitivity is the...
1.3K
Hazard Rate01:11

Hazard Rate

The hazard rate, also known as the hazard function or failure rate, is a statistical measure used to describe the instantaneous rate at which an event occurs, given that the event has not yet happened. From a probabilistic perspective, it represents the likelihood that a subject will experience the event in a very small time interval, conditional on surviving up to the beginning of that interval. In terms of frequency, the hazard rate can be viewed as the ratio of the number of events to the...
432
Hazard Ratio01:12

Hazard Ratio

The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
602
Predicting Molecular Geometry02:27

Predicting Molecular Geometry

VSEPR Theory for Determination of Electron Pair Geometries
45.7K
Relative Risk01:12

Relative Risk

Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.1K
Prediction Intervals01:03

Prediction Intervals

The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y. 
3.4K