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[Cardiac involvement in scleroderma].

L M Olivares1, J C Gatti, A Romorini

  • 1Facultad de Medicina, Universidad del Salvador, Buenos Aires.

Medicina Cutanea Ibero-Latino-Americana
|January 1, 1988
PubMed
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Progressive systemic sclerosis often impacts the heart, causing cardiac dysfunction and pulmonary hypertension. Early cardiac screening is vital, even without symptoms, for managing this autoimmune disease.

Area of Science:

  • Cardiology
  • Rheumatology
  • Medical Imaging

Background:

  • Progressive systemic sclerosis (PSS) is a multisystem autoimmune disease.
  • Cardiac involvement is a significant complication in PSS, affecting prognosis.
  • Early detection of cardiac abnormalities is crucial for patient management.

Purpose of the Study:

  • To evaluate cardiac function in patients with progressive systemic sclerosis.
  • To identify the prevalence of cardiac abnormalities in this patient cohort.
  • To assess the utility of radionuclide imaging in diagnosing cardiac complications of PSS.

Main Methods:

  • Seven patients (5 female, 2 male; age 35-60) with PSS underwent physical examination, electrocardiogram, echocardiogram, and radionuclide techniques.
  • Specific radionuclide techniques included Thallium-201 (T201) perfusion imaging and ventriculography (Tc99).

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  • Analysis focused on left and right ventricular function and myocardial perfusion.

    • Main Results:

    • Left myocardiopathy was observed in six patients, and right myocardiopathy in two.
    • Four patients presented with chronic cor pulmonale secondary to pulmonary hypertension.
    • Diffuse Thallium-201 perfusion defects were noted in all patients, with abnormal ventricular function in five.

    Conclusions:

    • Cardiac involvement, including myocardiopathy and pulmonary hypertension, is highly prevalent in PSS.
    • Radionuclide imaging effectively detects myocardial perfusion defects and ventricular dysfunction in PSS.
    • Systematic cardiac evaluation is recommended for all PSS patients, irrespective of cardiac symptoms.