Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chromatin Structure Regulates pre-mRNA Processing

Chromatin Structure Regulates pre-mRNA Processing

In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...

Hormonal Regulation

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

GTPases and their Regulation

GTPases and their Regulation

Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒ small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins,...

Respiratory Regulation of Acid-Base Balance

Respiratory Regulation of Acid-Base Balance

Respiratory compensation is a vital physiological process that stabilizes blood plasma pH by regulating the partial pressure of carbon dioxide (PCO2), a key determinant of pH levels. Most carbon dioxide in the blood dissolves and converts into carbonic acid (H2CO3). It dissociates into hydrogen ions (H+) and bicarbonate ions (HCO3⁻). There is also an inverse relationship between PCO2 and pH.
When carbon dioxide levels increase in the blood, more H+ and HCO3⁻ are...

Renal Regulation of Acid-Base Balance

Renal Regulation of Acid-Base Balance

Metabolic reactions in the body produce nonvolatile acids, such as sulfuric acid, which generate an acid load of approximately 1 mEq of H+ per kilogram of body weight daily. Excreting H+ in the urine is essential to balance this acid load.
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Exploring bet-hedging in <i>Salmonella enterica</i> serovar Typhimurium with a dual reporter strain.

mSystems·2026

Same author

Detecting local adaptation under weak genetic structure in an endemic damselfly: an integrative eco-evolutionary approach.

BMC ecology and evolution·2026

Same author

A Novel Self-Regulated, Non-Directional Magnetic Thermos-Brachytherapy <sup>125</sup>I Seed Enhances Anticancer Efficacy by Rescuing Immune Escape.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025

Same author

Research progress on surgical approach and intestinal anastomosis methods for laparoscopic right hemicolectomy: A review.

Medicine·2025

Same author

Requirement of CSR-1 isoforms and catalytic activity for <i>C. elegans</i> lifespan.

microPublication biology·2025

Same author

High-content cell imaging for chemical toxicity screening in the model organism Caenorhabditis elegans.

Journal of pharmacological and toxicological methods·2025

Search research articles

Related Experiment Video

Updated: Jan 29, 2026

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

Published on: September 29, 2017

Onion-structure bionic hydrogel capsules based on chitosan for regulating doxorubicin release.

Wei Zhang¹, Xin Jin¹, Heng Li¹

¹State Key Laboratory of Structure Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian 116024, China.

Carbohydrate Polymers

|February 9, 2019

Summary

Novel multilayer hydrogel capsules, inspired by onions, effectively inhibit doxorubicin (DOX) burst release. These capsules offer controlled drug delivery and show pH sensitivity and biocompatibility for potential therapeutic applications.

Keywords:

Bionic multilayer Burst release Drug delivery Hydrogel capsules pH-sensitive

More Related Videos

A Freeze-Thawing Method to Prepare Chitosan-Polyvinyl alcohol Hydrogels Without Crosslinking Agents and Diflunisal Release Studies

A Freeze-Thawing Method to Prepare Chitosan-Polyvinyl alcohol Hydrogels Without Crosslinking Agents and Diflunisal Release Studies

Published on: January 14, 2020

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

Published on: July 10, 2014

Related Experiment Videos

Last Updated: Jan 29, 2026

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

Published on: September 29, 2017

A Freeze-Thawing Method to Prepare Chitosan-Polyvinyl alcohol Hydrogels Without Crosslinking Agents and Diflunisal Release Studies

A Freeze-Thawing Method to Prepare Chitosan-Polyvinyl alcohol Hydrogels Without Crosslinking Agents and Diflunisal Release Studies

Published on: January 14, 2020

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

Published on: July 10, 2014

Area of Science:

Biomaterials Science
Drug Delivery Systems
Nanotechnology

Background:

Burst release of drugs from hydrogel capsules leads to suboptimal therapeutic outcomes.
Developing strategies to control drug release is crucial for effective drug delivery systems.

Purpose of the Study:

To develop bionic multilayer hydrogel capsules for inhibiting the burst release of doxorubicin (DOX).
To investigate the drug distribution, release kinetics, pH sensitivity, and biocompatibility of the developed capsules.

Main Methods:

Fabrication of bionic multilayer hydrogel capsules using ionotropic crosslinking.
Characterization of DOX distribution and release profiles.
Assessment of pH sensitivity and biocompatibility with human epidermal keratinocyte (HaCaT) cells.

Main Results:

Multilayer hydrogel capsules homogenized DOX distribution and suppressed concentration gradients.
Significant inhibition of DOX burst release was achieved compared to monolayer capsules.
The capsules exhibited pH sensitivity and good biocompatibility with HaCaT cells.

Conclusions:

Bionic multilayer hydrogel capsules provide an effective strategy to control drug release.
This approach offers a promising platform for advanced drug delivery systems with enhanced therapeutic efficacy.