Quantification of vestibular compensation in unilateral Meniere's disease

The main parameters of the vestibulo-ocular reflex (i.e. the gain or reflectivity, the long-time constant of the semicircular canals, the time constant of the mechano-neural transduction, and that of the central leaky integrator) were computed from the post-rotational nystagmic responses of unilateral Meniere's patients. Comparison with normal subjects showed a decrease of the first two parameters both in CW and CCW responses. No significant changes were observed in the remaining parameters. Probably due to a process of central compensation, a high level of symmetry was observed mainly in longstanding patients.