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Inflammation, infection and atherosclerosis

Prediman K Shah1

  • 1The Helga and Walter Oppenheimer Atherosclerosis Research Center, Cardiology Division and Smidt Heart Institute at Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA, United States.

Trends in Cardiovascular Medicine
|February 9, 2019
PubMed

Insights

Inflammation plays a key role in the development of atherosclerotic cardiovascular disease. Targeting inflammatory pathways offers a new strategy to prevent heart disease complications, complementing lifestyle changes and cholesterol reduction.

Area of Science:

  • Cardiovascular Science
  • Immunology
  • Pathophysiology

Background:

  • Atherosclerotic cardiovascular disease (ASCVD) is a major global health concern.
  • Current prevention strategies include lifestyle modification and lipid-lowering therapies.
  • Emerging research highlights the significant role of inflammation in ASCVD.

Purpose of the Study:

  • To explore the role of innate and adaptive immune pathways in the pathophysiology of atherosclerosis.
  • To identify opportunities for anti-inflammatory interventions in ASCVD prevention.
  • To evaluate how anti-inflammatory approaches can supplement existing risk factor management.

Main Methods:

  • Review of recent data on immune pathways in atherosclerosis.
  • Analysis of inflammatory mechanisms in the development of atherosclerotic plaques.
  • Assessment of potential therapeutic targets within immune signaling cascades.

Main Results:

  • Inflammation, mediated by innate and adaptive immunity, is critical in ASCVD.
  • Activation of specific immune pathways contributes to atherosclerotic plaque progression.
  • These findings suggest inflammation is a viable therapeutic target.

Conclusions:

  • Targeting inflammation presents a promising avenue for ASCVD prevention.
  • Anti-inflammatory therapies could enhance current lipid-lowering and lifestyle interventions.
  • Further research into immune-mediated pathways may reduce the global burden of cardiovascular disease.

Keywords:
AtherosclerosisVascular inflammation

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