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Challenges to curing primary brain tumours

Kenneth Aldape1, Kevin M Brindle2, Louis Chesler3

  • 1Department of Pathology, University Health Network, Toronto, Ontario, Canada.

Nature Reviews. Clinical Oncology
|February 9, 2019
PubMed

Insights

Brain tumors are deadly due to their resistance to treatments, stemming from unique neural tissue properties. Addressing seven key challenges is crucial for advancing brain tumor research and patient outcomes.

Area of Science:

  • Neuro-oncology
  • Cancer Research
  • Translational Medicine

Background:

  • Brain tumors represent a significant challenge in oncology, demonstrating high mortality rates despite extensive research.
  • Treatment resistance in brain tumors is partly attributed to the specific cell-intrinsic and microenvironmental characteristics of neural tissues.

Purpose of the Study:

  • To identify critical challenges hindering progress in brain tumor research and treatment.
  • To guide future research directions and investment by outlining key obstacles.

Main Methods:

  • Convened an international panel of experts in clinical and laboratory-based brain tumor research.
  • Synthesized expert consensus on the most significant hurdles in the field.

Main Results:

  • Identified seven key challenges that impede the successful treatment and cure of brain tumors.
  • These challenges encompass both fundamental biological and clinical aspects of brain tumor progression and therapy.

Conclusions:

  • Overcoming these seven identified challenges is essential for advancing the field of neuro-oncology.
  • Targeted research and investment focused on these challenges are necessary to improve outcomes for patients with brain tumors.

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