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The effect of azone on ocular levobunolol absorption: calculating the area under the curve and its standard error
1Department of Pharmacokinetics, Allergan, Inc., Irvine, California 92715.
Pharmaceutical Research
|April 1, 1988
Abstract:
Methods of calculating the area under the concentration-time curve and the associated standard error are proposed for studies in which each animal contributes one independent data point to a pool of data. This approach can be used for data analysis in bioequivalence studies employing tissue sampling compartments. Application of this method indicated that an azone-containing ophthalmic formulation of levobunolol did not produce better ocular bioavailability than a formulation containing no penetration enhancer.