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Transfusion-associated circulatory overload in ambulatory patients
Jock D Simpson1,2, Adam Hopkins2, Adilah Amil2
1Haematology Department, Calvary Mater Newcastle, Waratah, NSW, Australia.
Vox Sanguinis
|February 9, 2019
Summary
Transfusion-associated circulatory overload (TACO) is rare in ambulatory hematology patients. However, 8% of transfusion encounters showed risk of clinically significant hypervolemia (ROCSH), with age being a significant factor.
Area of Science:
- Hematology
- Transfusion Medicine
- Patient Safety
Background:
- Transfusion-associated circulatory overload (TACO) is a significant cause of adverse events.
- The incidence and risk factors for TACO in ambulatory hematology patients are not well-established.
Purpose of the Study:
- To determine the frequency and risk factors for TACO in ambulatory hematology patients.
- To establish baseline data for future hemovigilance studies.
Main Methods:
- Retrospective cohort analysis of ambulatory patients transfused between January and December 2014.
- Utilized medical records and an electronic transfusion database.
- Defined TACO using International Society of Blood Transfusion criteria and identified 'risk of clinically significant hypervolemia' (ROCSH).
Main Results:
- No cases of TACO were reported in 93 ambulatory patients (715 transfusion encounters).
- 8% of transfusion encounters (57/715) met the criteria for ROCSH.
- Older age was significantly associated with ROCSH (OR=1.05, P=0.017) in univariate analysis.
Conclusions:
- TACO is infrequent in ambulatory hematology patients undergoing blood transfusions.
- This study provides the first report on TACO occurrence and risk factors in this population.
- Findings offer crucial baseline data for future hemovigilance research.
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