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Recent Advances in Pathology: the 2019 Annual Review Issue of The Journal of Pathology

C Simon Herrington1, Richard Poulsom2, Philip J Coates3

  • 1Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

The Journal of Pathology
|February 9, 2019
PubMed

Insights

This review issue highlights 15 expert-authored updates on key pathology topics. It covers microbiome impacts, cell death, immunity, and genomics in cancer for disease understanding and treatment.

Area of Science:

  • Pathology
  • Molecular Biology
  • Genomics
  • Immunology

Background:

  • The Journal of Pathology presents an Annual Review Issue.
  • This issue features 15 invited reviews on current pathology topics.
  • Reviews are authored by leading experts in their respective fields.

Purpose of the Study:

  • To provide comprehensive updates on recent progress in specific areas of pathology.
  • To cover a range of topical aspects including microbiome, cell death, immunity, and cancer genomics.
  • To serve as a valuable resource for researchers and clinicians.

Main Methods:

  • Compilation of 15 invited review articles.
  • Expert contributions covering diverse pathology sub-disciplines.
  • Focus on areas with significant recent advancements.

Main Results:

  • Comprehensive updates on the microbiome's role in human disease.
  • Detailed insights into mechanisms of cell death and autophagy.
  • Latest advances in immunology and cancer genomics applications.
  • Genomic approaches for cancer classification and treatment.

Conclusions:

  • The issue offers a broad overview of cutting-edge pathology research.
  • It synthesizes recent progress across multiple critical areas of the discipline.
  • Provides essential information for understanding and advancing human disease research and treatment.
Keywords:
ARDSCD44DAMPDNA damage responseEndoPredict (EPclin)Epstein-Barr virusFoxO3AGATA3Group 2 innate lymphoid cellsILC2KRT5MLKLMammaPrintMapQuantDxNanoStringOncotypeDXPAMPPD-1PD-L1PPARgammaRB1TGFbetaTP53VUSabscopal responseacralacute kidney injury, transplantationadaptive immunityalveolarisationapoptosisautoimmunityautophagybasal-like bladder cancerbiobankbioinformaticsbiomarkersbreast cancerbreast cancer indexbronchopulmonary dysplasiacancer genescancer predispositioncancer stem cellcancer syndromescaspase-3checkpoint inhibitorschemokinechemopreventionchronic inflammationcirculating tumour DNA (ctDNA)cutaneousdesmoplasticdormancydriver genesdrug resistancedysbiosisextracellular matrixfamilial adenomatous polyposisferroptosisfibroblastsgasdermingenomic signatureshedgehoghereditary colorectal cancerhypoxiaimaging mass cytometryimmune-oncologyin situ hybridisationinflammationinnate immunityinterferoninterleukinleukotrieneliquid biopsylung cancer, small cell lung cancer, pathology, molecular genetics, in vitro modelslung developmentlymphatic systemlynch syndromemacrophagesmassively parallel sequencingmatrix metalloproteinasemelanomametastasismicrobiotamismatch repair, microsatellite instabilitymitochondriamucosalmultiplexed immunohistochemistrymultiplexed ion beam imagingmuscle-invasive bladder cancermutationsmyeloid-derived suppressor cellsnasopharyngeal carcinomanecroptosisneutrophil extracellular trapsneutrophilspolyposispopulation health sciencepostnatal developmentpredictiveprognosticprognostic signaturesprosignaproteasepyroptosisquiescenceradiationreactive oxygen speciesrespiratory infectionscreeningsevere inflammatory response syndromesize-based diagnosticsstatisticsstem cellstissue biomarkerstoll-like receptortranslational researchtriple negative breast cancertumour invasiontumour microenvironmenttumour progressiontumour-infiltrating lymphocytestype 2 immunityurothelial carcinomauvealvariants of uncertain significance

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