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Related Concept Videos

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Related Experiment Video

Updated: Jan 29, 2026

Focal Laser Ablation of Prostate Cancer: An Office Procedure
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Focal Laser Ablation of Prostate Cancer: An Office Procedure

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[Focal therapy for prostate cancer].

M Schostak1

  • 1Urologische Universitätsklinik, Universitätsklinikum Magdeburg A.ö.R., Leipziger Str. 44, 39120, Magdeburg, Deutschland. martin.schostak@med.ovgu.de.

Der Urologe. Ausg. A
|February 9, 2019
PubMed
Summary

Focal therapy offers potential for similar cancer control as whole gland treatment with fewer side effects. However, precise diagnosis and further research are needed, as focal therapy is still considered experimental.

Keywords:
Fusion biopsyMRIPartial gland ablationProstate cancerTherapy

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Area of Science:

  • Urology
  • Oncology
  • Medical Imaging

Background:

  • Focal therapy (FT) aims to match whole gland therapy's oncological efficacy while reducing side effects.
  • Precise diagnosis using PI-RADS v2 multiparametric MRI and fusion biopsy is essential for FT.
  • Various ablation technologies and hemiablation strategies have emerged for FT.

Purpose of the Study:

  • To evaluate the role and current status of focal therapy in prostate cancer treatment.
  • To highlight the prerequisites, challenges, and future directions for focal therapy.
  • To define the place of FT in clinical practice, especially for intermediate-risk localized prostate cancer.

Main Methods:

  • Review of current literature and available randomized studies on focal therapy.
  • Emphasis on diagnostic accuracy with multiparametric MRI and biopsy techniques.
  • Consideration of different ablation modalities and treatment strategies.

Main Results:

  • Focal therapy requires precise diagnosis and is currently considered experimental, necessitating study participation.
  • Treatment success definitions remain inconsistent across studies.
  • A single large randomized study compares FT to standard therapy.

Conclusions:

  • Focal therapy is best suited for highly localized, intermediate-risk prostate cancers when standard options are refused or unsuitable.
  • Individualized treatment selection ('à la carte') considering ablation technique and gland region is ideal.
  • Follow-up protocols should align with active surveillance, including MRI and fusion biopsy.