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Updated: Jan 29, 2026

Age-dependent Dynamics of Locomotion in Caenorhabditis elegans: A Lyapunov Exponent Analysis
Published on: September 23, 2025
Age-dependent changes and biomarkers of aging in Caenorhabditis elegans
Heehwa G Son1, Ozlem Altintas2, Eun Ji E Kim1
1Department of Life Sciences, Pohang University of Science and Technology, Pohang, South Korea.
Abstract:
Caenorhabditis elegans is an exceptionally valuable model for aging research because of many advantages, including its genetic tractability, short lifespan, and clear age-dependent physiological changes. Aged C. elegans display a decline in their anatomical and functional features, including tissue integrity, motility, learning and memory, and immunity. Caenorhabditis elegans also exhibit many age-associated changes in the expression of microRNAs and stress-responsive genes and in RNA and protein quality control systems. Many of these age-associated changes provide information on the health of the animals and serve as valuable biomarkers for aging research. Here, we review the age-dependent changes in C. elegans and their utility as aging biomarkers indicative of the physiological status of aging.
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