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Published on: January 9, 2019
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Parallel pathways for sound processing and functional connectivity among layer 5 and 6 auditory corticofugal neurons
Ross S Williamson1,2, Daniel B Polley1,2
1Eaton-Peabody Laboratories, Massachusetts Eye and Ear Infirmary, Boston, United States.
Elife
|February 9, 2019
Summary
Auditory cortex Layer 5 corticofugal (CF) neurons broadcast sensory information, while Layer 6 corticothalamic (CT) neurons regulate thalamocortical gain and selectivity. This study reveals distinct functional roles for these projection neuron types.
Area of Science:
- Neuroscience
- Auditory Cortex Research
- Cellular Electrophysiology
Background:
- Cortical layers 5 and 6 contain diverse neuron types with unique connectivity.
- Understanding the functional roles of these neurons is crucial for deciphering brain processing.
Purpose of the Study:
- To differentiate sensory processing and functional connectivity between Layer 5 corticofugal (CF) and Layer 6 corticothalamic (CT) neurons in the auditory cortex.
- To elucidate the distinct roles of these sub-cortical projection neurons.
Main Methods:
- Optogenetically guided in vivo recordings from L5 CF and L6 CT neurons in awake mice.
- Analysis of stimulus selectivity, response latencies, temporal nonlinearities, and functional connectivity patterns.
Main Results:
- L5 CF neurons displayed broad stimulus selectivity, slow responses, and weak local excitation.
- L6 CT neurons showed sparse selectivity, rapid processing, and robustly drove local interneurons.
- Distinct temporal dynamics and connectivity patterns were observed between L5 CF and L6 CT neurons.
Conclusions:
- A functional duality exists between L5 CF and L6 CT neurons.
- L5 CF neurons act as broadcast neurons integrating sensory input for widespread targets.
- L6 CT neurons are critical for modulating thalamocortical gain and selectivity.
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