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Updated: Jan 29, 2026
05:19
A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
Published on: November 7, 2025
844
Long-term Outcomes of Stereotactic Body Radiotherapy for Low-Risk and Intermediate-Risk Prostate Cancer.
Amar U Kishan1,2, Audrey Dang2, Alan J Katz3
1Department of Urology, University of California, Los Angeles.
JAMA Network Open
|February 9, 2019
Summary
Stereotactic body radiotherapy for low- and intermediate-risk prostate cancer shows high biochemical control and low severe toxicity rates. This approach is a suitable definitive treatment option, offering excellent long-term outcomes.
Area of Science:
- Oncology
- Radiation Therapy
- Prostate Cancer Treatment
Background:
- Stereotactic body radiotherapy (SBRT) offers a shortened treatment course for prostate cancer.
- While short-term data are promising, long-term outcomes of SBRT for prostate cancer remain underreported.
Purpose of the Study:
- To evaluate the long-term efficacy and safety of SBRT in patients with low-risk and intermediate-risk prostate cancer.
Main Methods:
- A cohort study analyzed data from 2142 men treated with SBRT between 2000-2012.
- Biochemical recurrence was assessed using competing risk analysis, and toxic events were graded using standard criteria.
- Long-term follow-up data were collected until May 2018.
Main Results:
- At a median follow-up of 6.9 years, 7-year biochemical recurrence rates were 4.5% (low-risk) and 10.2% (intermediate-risk).
- The cumulative incidence of late grade 3+ genitourinary toxicity was 2.4%, and gastrointestinal toxicity was 0.4%.
- Acute grade 3+ toxicities were rare (GU: 0.60%, GI: 0.09%).
Conclusions:
- SBRT demonstrates high rates of biochemical control for low- and intermediate-risk prostate cancer.
- The treatment is associated with low rates of severe long-term toxic events.
- SBRT is a viable and effective definitive treatment option for these patient groups.
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