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Small Molecule SOS1 Agonists Modulate MAPK and PI3K Signaling via Independent Cellular Responses

Denis T Akan1, Jennifer E Howes1, Jiqing Sai1

  • 1Department of Biochemistry , Vanderbilt University School of Medicine , 2215 Garland Avenue, 607 Light Hall , Nashville , Tennessee 37232-0146 , United States.

ACS Chemical Biology
|February 9, 2019
PubMed
Summary

Targeting SOS1 with novel agonists modulates RAS signaling, impacting both MAPK and PI3K pathways. Researchers identified a potent SOS1 agonist with rapid, on-target effects, advancing therapeutic strategies for RAS-driven cancers.

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