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ETV5 regulates GOAT/ghrelin system in an mTORC1-dependent manner
Zhuo Mao1, Qing Yang1, Wenzhen Yin2
1Center for Diabetes, Obesity and Metabolism, Department of Physiology, Shenzhen University Health Science Center, Shenzhen, Guangdong province, 518000, China.
Molecular and Cellular Endocrinology
|February 9, 2019
Summary
The study identifies a new pathway regulating ghrelin, a key metabolic hormone. ETV5 activates ghrelin-O-acyl-transferase (GOAT) production, influenced by mTORC1, impacting acyl ghrelin levels and energy balance.
Area of Science:
- Metabolic regulation
- Endocrinology
- Molecular biology
Background:
- Ghrelin is a peptide hormone crucial for metabolic functions.
- Acylation by ghrelin-O-acyl-transferase (GOAT) is essential for ghrelin receptor activation.
- The regulatory mechanisms of GOAT and acyl ghrelin are not fully understood.
Purpose of the Study:
- To elucidate the regulatory mechanisms of GOAT and acyl ghrelin production.
- To investigate the role of ETV5 in the ghrelin system.
- To explore the connection between mTORC1 signaling and ghrelin regulation.
Main Methods:
- Analysis of GOAT promoter activity.
- Measurement of acyl ghrelin production.
- Investigation of ETV5 expression and its modulation by mTORC1 in cell lines and animal models.
Main Results:
- ETV5 was found to transactivate the GOAT promoter, increasing GOAT expression and acyl ghrelin production.
- mTORC1 signaling was shown to modulate ETV5 expression, potentially through protein stability.
- ETV5 was identified as a mediator of mTORC1's effects on acyl ghrelin levels.
Conclusions:
- A novel mTORC1-ETV5-GOAT/ghrelin axis regulating the ghrelin system was discovered.
- ETV5 acts as a key regulator in this axis within ghrelin-producing cells.
- ETV5 presents a potential therapeutic target for addressing energy imbalance disorders.
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