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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Peripheral Nervous System: Ganglia and Nerves01:24

Peripheral Nervous System: Ganglia and Nerves

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The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
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Curing of Concrete01:20

Curing of Concrete

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The hydration of cement takes place within the water-filled capillary pores. However, environmental elements can disrupt this process by evaporating water from the concrete surfaces. Sealed concrete with a water-cement ratio below 0.5 experiences self-desiccation, leading to water loss. The water loss in concrete is mitigated by curing. This technique involves keeping the concrete saturated to maintain the necessary temperature and moisture conditions, to optimally fill the spaces in the cement...
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Curing Methods01:26

Curing Methods

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Concrete members with a small surface-to-volume ratio are cured by oiling and moistening the forms before casting the concrete member. These forms can be left in place for a prolonged period to prevent moisture loss, and can be wetted if made of a material suitable for wetting. If the forms are removed early, the concrete member is moistened and covered with polythene sheets to maintain moisture. For large horizontal concrete surfaces exposed to dry weather, a temporary covering is suspended...
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Accelerated Curing of Concrete01:25

Accelerated Curing of Concrete

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Accelerating concrete curing is achieved by applying heat and additional moisture. This process accelerates the hydration of the cement, resulting in an earlier strength gain in the concrete. Steam curing is a method wherein the concrete products are either transported through a chamber on a conveyor belt or encased in plastic, allowing steam at atmospheric pressure to circulate freely around them. This process begins with a phase of moist curing that typically lasts between 3 to 5 hours, after...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Related Experiment Video

Updated: Jan 29, 2026

Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury
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Novel approaches using mesenchymal stem cells for curing peripheral nerve injuries.

Forouzan Yousefi1, Fahimeh Lavi Arab1, Karim Nikkhah2

  • 1Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Life Sciences
|February 9, 2019
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Peripheral nerve injury (PNI) treatment is advancing with mesenchymal stem cells (MSCs). This review explores biotechnological innovations for PNI using MSCs, offering a promising alternative to traditional methods.

Keywords:
Mesenchymal stem cellsPeripheral nerve injuries

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Biotechnology

Background:

  • Peripheral nerve injury (PNI) is a prevalent cause of disability with significant socioeconomic impact.
  • Current treatments for PNI involve autologous nerve grafting, requiring additional surgery and donor nerve limitations.
  • Mesenchymal stem cells (MSCs) show promise as a safe and effective therapy for nervous system disorders.

Purpose of the Study:

  • To review recent biotechnological advancements in treating peripheral nerve injuries.
  • To highlight the potential of mesenchymal stem cells (MSCs) as a therapeutic strategy for PNI.
  • To discuss the advantages of MSCs over conventional PNI treatments.

Main Methods:

  • Literature review of recent studies on MSCs for PNI treatment.
  • Analysis of biotechnological approaches utilizing MSCs in preclinical and clinical settings.
  • Synthesis of findings on MSC efficacy and safety in PNI regeneration.

Main Results:

  • MSCs demonstrate neuroprotective and neuroregenerative properties relevant to PNI.
  • Biotechnological strategies enhance MSC survival, delivery, and therapeutic potential for PNI.
  • Emerging evidence supports MSCs as a viable alternative to conventional PNI therapies.

Conclusions:

  • Mesenchymal stem cells offer a promising, less invasive therapeutic avenue for peripheral nerve injury.
  • Biotechnological advancements are crucial for optimizing MSC-based therapies for PNI.
  • Further research is warranted to translate MSC potential into widespread clinical application for PNI.