The association between gestational diabetes and postpartum depression: A systematic review and meta-analysis

Postpartum period is a critical period for mothers, which is often accompanied by increased risk of depression. Many studies have evaluated the relationship between gestational diabetes (GDM) and postpartum depression (PPD), but contradictory results have been reported. Therefore, the present study was conducted to investigate the relationship between GDM and PPD.

This systematic review and meta-analysis was conducted based on PRISMA Guideline. We searched all the relevant epidemiological studies in international databases of Scopus, PubMed, Science Direct, Embase, Web of Science, CINAHL, Cochrane Library, EBSCO, and Google scholar search engine using the MeSH Keywords in English without time limit until 2018. The heterogeneity of the studies was calculated using the I² index and Cochran's Q test. Relative risk (RR) and 95% confidence interval (CI) were extracted from each study. The results of the study were analyzed using the random effects model and Comprehensive Meta-Analysis Software Version 2.

A total of 18 studies with a sample size of 2,370,958 were reviewed. Meta-analysis results showed that GDM significantly increased the risk of PPD, and RR was 1.59 (95% CI: 1.22-2.07, p = 0.001). The RR for 15 cohort studies, 2 cross-sectional studies and 1 case-control study was 1.67 (95% CI: 1.22-2.28), 1.37 (95% CI: 0.91-2.05), and 1.29 (95% CI: 0.98-1.68), respectively.

GDM can be a risk factor for PPD. Therefore, PPD examination in pregnant women with GDM seems to be necessary.