Related Experiment Video
Updated: Jan 29, 2026

Procedures of Laboratory Fumigation for Pest Control with Nitric Oxide Gas
Published on: November 24, 2017
Controlled light-induced gas phase nitric oxide release from S-nitrosothiol-doped silicone rubber films
Gergely Lautner1, Blake Stringer2, Elizabeth J Brisbois3
1Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA.
Abstract:
The light induced nitric oxide (NO) release properties of S-nitroso-N-acetylpenicillamine (SNAP) and S-nitrosoglutathione (GSNO) NO donors doped within polydimethylsiloxane (PDMS) films (PDMS-SNAP and PDMS-GSNO respectively) for potential inhaled NO (iNO) applications is examined. To achieve photolytic release of gas phase NO from the PDMS-SNAP and PDMS-GSNO films, narrow-band LED light sources are employed and the NO concentration in a N2 sweep gas above the film is monitored with an electrochemical NO sensor. The NO release kinetics using LED sources with different nominal wavelengths and optical power densities are reported. The effect of the NO donor loading within the PDMS films is also examined. The NO release levels can be controlled by the LED triggered release from the NO donor-doped silicone rubber films in order to generate therapeutic levels in a sweep gas for suitable durations potentially useful for iNO therapy. Hence this work may lay the groundwork for future development of a highly portable iNO system for treatment of patients with pulmonary hypertension, hypoxemia, and cystic fibrosis.
More Related Videos
Related Concept Videos
Nitric Oxide Signaling Pathway
Phase-lead and Phase-lag Controllers
Phase I Oxidative Reactions: Overview
Gas Chromatography: Types of Columns and Stationary Phases
For an analyte to remain on the column for a sufficient amount of time, it must exhibit some level of compatibility (or...
Phase Diagrams
Phase I Reactions: Oxidation of Carbon-Heteroatom and Miscellaneous Systems
In carbon-nitrogen systems, aliphatic and aromatic amines can undergo oxidative reactions. Secondary and tertiary amines, like those found in tricyclic antidepressants, can undergo N-dealkylation, a process that involves the oxidation of the alkyl group. In addition, oxidative...

