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Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
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Related Experiment Video

Updated: Jan 29, 2026

In Silico Clinical Trials for Cardiovascular Disease

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

IGF-1 and cardiovascular disease.

Yusuke Higashi¹, Sandeep Gautam², Patrick Delafontaine²

¹Department of Medicine, School of Medicine, University of Missouri, Columbia, MO, United States; Harry S. Truman Memorial Veterans' Hospital, Columbia, MO, United States.

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society

|February 9, 2019

Summary

Insulin-like growth factor 1 (IGF-1) shows promising atheroprotective effects in cardiovascular disease research. Studies suggest IGF-1 may mitigate atherosclerosis development and progression.

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Area of Science:

Cardiovascular Biology
Endocrinology
Molecular Medicine

Background:

Atherosclerosis is a complex inflammatory disease leading to ischemic cardiovascular events.
Multiple cell types and genetic factors contribute to atherosclerosis pathogenesis.
Insulin-like Growth Factor 1 (IGF-1) plays a role both systemically and locally in arteries.

Purpose of the Study:

To review recent clinical and basic research on the relationship between IGF-1 and cardiovascular disease.
To elucidate the mechanisms behind the atheroprotective effects of IGF-1.

Main Methods:

Analysis of clinical investigations linking IGF-1 levels to cardiovascular disease.
Review of findings from animal models of atherosclerosis studying IGF-1's role.

Main Results:

Growing evidence indicates beneficial effects of IGF-1 in atherosclerosis biology.
IGF-1 influences vascular endothelial cells, smooth muscle cells, and macrophages.

Conclusions:

IGF-1 demonstrates potential atheroprotective properties.
Further research into IGF-1 mechanisms could inform cardiovascular disease therapies.