Nanobiosensors: Point-of-care approaches for cancer diagnostics

Early cancer diagnosis is of prime importance as it paves the way for effective treatment and possible patient survival. The recent advancements in the field of biosensorics have facilitated the development of functionalized nanobiosensors which have the potential to provide a cost-effective, reliable and rapid diagnostic strategy for cancers. These nanoscaled sensing systems utilize electrochemical, optical, mass and calorimetric sensing mechanisms to specifically identify the disease-specific biomarkers. Because of clinical translational utility, the present review aims to describe the recent developments and status of the nanobiosensors as a point-of-care approach for cancer diagnosis. The review also offers important insights into the design, preparation and characterization of these nano-frameworks. In particular, the state-of-art nanobiosensors based on carbon nanostructures, metal nanoparticles, magnetic nanoparticles, silica-based nanomaterials, conducting polymers based nanoparticles and quantum dots, which provide countless opportunities in the field of cancer biosensorics have been summarized. It also showcases the need to perform robust clinical validation of the emerging nanobiosensor strategies that would act as the ultimate point-of-care test for the personalized cancer therapeutics.