Pituitary incidentalomas: application of an evidence-based approach at the individual patient and population levels

With the widespread use of imaging techniques, incidental discovery of clinically unsuspected pituitary adenomas is increasing in frequency and will increase further. The Endocrine Society Task Force on Pituitary Incidentalomas has developed practice guidelines which reflect the best available evidence combined with the opinions of experts in pituitary diseases. For incidental macroadenomas, evidence supporting comprehensive evaluation (for hyperfunction, hypopituitarism and anatomy) and management (whether surgical or careful follow-up) is strong. By contrast, evidence supporting approaches to microadenomas without clinical suggestion of hormonal hypersecretion are relatively weak and practice varies. Developing more evidence will require approaches other than randomized controlled trials, such as comparative effectiveness studies. Incidentalomas represent part of a larger societal issue, that being overdiagnosis and its consequences.