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Estrogen and cognitive functions.

Antonella Gasbarri1, Assunta Pompili2, Maria Clotilde Tavares3

  • 1a Department of Biomedical Sciences and Technologies, Faculty of Sciences of Education, University of L'Aquila, via Vetoio, 67100 L'Aquila, Italy. antonella.gasbarri@cc.univaq.it.

Expert Review of Endocrinology & Metabolism
|February 10, 2019
PubMed
Summary
This summary is machine-generated.

Estrogen significantly impacts cognitive functions, particularly working memory, across various mammals. This review explores estrogen

Keywords:
cognitionestrogenestrogen receptorlearning and memoryworking memory

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Cognitive Psychology

Background:

  • Estrogen's well-established role in sexual behavior contrasts with its recently recognized influence on cognition.
  • Understanding estrogen's neurobiological effects is crucial for comprehending cognitive function.
  • Cognitive decline is a significant concern in aging and various diseases.

Purpose of the Study:

  • To review the effects of estrogen on cognitive functions in mammals.
  • To explore the neurobiological underpinnings of estrogen's cognitive effects.
  • To discuss the relevance of these findings to human health, disease, and aging.

Main Methods:

  • Literature review of laboratory research and published studies.
  • Synthesis of findings on estrogen's impact on cognitive behaviors.
  • Analysis of neurobiological mechanisms and physiological relevance.

Main Results:

  • Estrogen influences a range of cognitive behaviors in mammals.
  • Specific focus on estrogen's role in working memory across species (humans, nonhuman primates, rodents).
  • Evidence suggests a link between estrogen and the aging brain's cognitive health.

Conclusions:

  • Estrogen plays a significant role in cognitive functions, including working memory.
  • These effects have implications for understanding human cognitive health and disease.
  • Further research into estrogen's relationship with the aging brain is warranted.