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Updated: Jan 29, 2026

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
Published on: October 6, 2023
Impact of endocrine-disrupting chemicals on thyroid function and brain development
Kingsley Ibhazehiebo1, Noriyuki Koibuchi2
1a Department of Medical Genetics, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada.
Abstract:
Endocrine disrupting chemicals (EDCs) are synthetic or natural substances in the environment. EDCs have been shown to disrupt reproductive, developmental and other homeostatic systems by interfering with the synthesis, secretion, transport, metabolism and action of endogenous hormones including the thyroid hormone (TH) system. Since TH plays a critical role in brain development, the exposure to TH-system disrupting EDCs during development may have serious consequences. In this article, representative previous studies showing the effect of representative EDCs on the TH system are summarized. Then, the molecular mechanisms of action of polychlorinated biphenyls and polybrominated diphenyl ethers on the TH system are discussed further. Particularly, the effect of polychlorinated biphenyls and polybrominated diphenyl ethers on TH-mediated brain development is discussed. Our recent studies may provide a novel idea regarding the effect of EDCs on the TH system.
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