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Selenium status in patients with autoimmune and non-autoimmune thyroid diseases from four European countries
Gerasimos E Krassas1, Nikolaos Pontikides1, Kostas Tziomalos1
1a Department of Endocrinology, Diabetes and Metabolism, Panagia General Hospital, Tsimiski 92, 54622 Thessaloniki, Greece.
Context:
Selenium supplementation has been suggested for Hashimoto thyroiditis and Graves' ophthalmopathy. Objective, Design: Our aim is to measure selenium status (p-Se, p-SePP), urine iodine (UI) levels and urine iodine/creatinine ratio (UI/C) in different thyroid diseases (n = 416) from four European countries and to compare the results between patients with and without thyroid autoimmunity.
Results:
p-Se and p-SePP showed positive correlation and did not correlate with UI/C. Also, these measurements were higher in patients from Italy in comparison with the other countries. Austria had the lowest UI/C ratios. Selenium deficiency exists in these four European countries. Selenium status was lower in patients with Hashimoto thyroiditis and Graves' disease in comparison with non-autoimmune thyroid disease patients and did not differ between autoimmune patients with or without thyroid peroxidase antibodies. The latter correlated positively with age.
Conclusions:
Our findings suggest that Se supplementation might have a beneficial effect in autoimmune thyroid patients.
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