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Lactobacillus mucosae DPC 6426 as a bile-modifying and immunomodulatory microbe
Paul M Ryan1,2, Ellen H Stolte3, Lis E E London1
1Teagasc Food Research Centre, Food Biosciences Department, Moorepark, Fermoy, Co, Cork, Ireland.
BMC Microbiology
|February 10, 2019
Summary
Lactobacillus mucosae DPC 6426 modifies bile acid profiles and stimulates immune responses. These actions may explain its previously observed cardio-protective effects in preclinical models.
Area of Science:
- Microbiology
- Immunology
- Cardiovascular Science
Background:
- Lactobacillus mucosae DPC 6426 shows potential cardio-protective effects.
- Previous studies noted its ability to correct dyslipidemia and hypercholesterolemia in mice.
- This study investigates its mechanisms involving bile and immune modulation.
Purpose of the Study:
- To characterize how Lactobacillus mucosae DPC 6426 influences host bile composition.
- To understand its impact on the immune response in the context of cardiovascular disease.
- To assess its bile salt hydrolase activity and immunomodulatory properties.
Main Methods:
- Assessed bile salt hydrolase activity and specificity of Lactobacillus mucosae DPC 6426.
- Performed bile acid profiling after incubation with the microbe.
- Investigated immunomodulatory effects of exopolysaccharide and secretome using RAW264.7 macrophages.
Main Results:
- Lactobacillus mucosae DPC 6426 exhibited significant bile salt hydrolase activity, preferring glyco-conjugated bile acids.
- Its exopolysaccharide and secretome modulated immune responses in macrophages, increasing IL-6, IL-10, and TNF-α.
- Specific fractions influenced gene transcription of IL-6, IL-10, and CD206.
Conclusions:
- Lactobacillus mucosae DPC 6426 modulates bile pool composition and immune tone.
- These modulations are likely contributors to its cardio-protective effects.
- The study provides mechanistic insights into the probiotic's cardiovascular benefits.
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