Related Experiment Video

Updated: Jan 29, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

20.6K

Polysomnographic Analysis of a Pediatric Case of Baclofen-Induced Central Sleep Apnea

Federica Locatelli1, Francesca Formica1, Sara Galbiati1

  • 1Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Lecco, Italy.

Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine
|February 10, 2019
PubMed

Insights

Baclofen dose increases can cause central sleep apnea in pediatric patients with brain injuries. Polysomnography can diagnose this condition, and baclofen dose reduction can resolve it.

Area of Science:

  • Neurology
  • Pulmonology
  • Clinical Pharmacology

Background:

  • Brain injury can lead to respiratory disorders, exacerbated by medications like central depressants.
  • Sleep can precipitate respiratory issues, making polysomnography a key diagnostic method.
  • Polysomnography identifies breathing patterns linked to sleep disorders and adverse drug effects.

Observation:

  • A pediatric patient with brain injury developed central sleep apnea after a therapeutic baclofen dose increase.
  • The patient was also on an under-dosed benzodiazepine.
  • Polysomnography revealed a respiration pattern associated with baclofen and central depressant use.

Findings:

  • Central sleep apnea in the pediatric patient was directly linked to the baclofen dose escalation.
  • The observed respiration pattern during polysomnography is consistent with prior adult studies on baclofen.
  • Tapering baclofen successfully resolved the central sleep apnea.

Implications:

  • Polysomnography, with its specific pattern recognition, can aid in diagnosing baclofen-induced central sleep apnea in children.
  • This diagnostic approach may help prevent respiratory complications in pediatric patients on baclofen.
  • Identifying and managing drug-induced sleep disorders is crucial in brain injury rehabilitation.

Keywords:
baclofenpediatricpolysomnographyrehabilitationsleep-disordered breathing

More Related Videos

Multi-Modal Home Sleep Monitoring in Older Adults07:40

Multi-Modal Home Sleep Monitoring in Older Adults

Published on: January 26, 2019

8.3K
Quantitative Measurement of the Immune Response and Sleep in Drosophila12:16

Quantitative Measurement of the Immune Response and Sleep in Drosophila

Published on: December 4, 2012

16.0K

Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
549
Central Tendency: Analysis01:10

Central Tendency: Analysis

Measures of central tendency are tools used in biostatistics to identify the average or center of a dataset. They offer a single representative value for understanding and summarizing data distribution.
The mean is one such measure, calculated by totaling all values in a dataset and dividing by the number of values. For instance, the mean blood pressure reading (120, 130, 140, 150) would be 135. However, the mean can be affected by extreme values or outliers.
The median, another measure,...
507
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
932
The Central Dogma01:25

The Central Dogma

Overview
139.7K
Stages of Sleep01:22

Stages of Sleep

Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
1.4K
Understanding Sleep01:11

Understanding Sleep

Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
1.5K