Related Experiment Video

Updated: Jan 29, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

7.6K

Ischemic stroke in giant-cell arteritis: French retrospective study

Aaron Pariente1, Alexis Guédon2, Sonia Alamowitch3

  • 1Service de Médecine Interne-DHU i2B, Hôpital Saint-Antoine, APHP, 75012, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMRS 938, CdR Saint-Antoine, France.

Journal of Autoimmunity
|February 10, 2019
PubMed

Insights

Giant cell arteritis (GCA) patients experiencing stroke have significantly lower survival rates and relapse-free survival. This study identified stroke prevalence and risk factors in GCA, highlighting older age and male sex as key indicators.

Area of Science:

  • Neurology
  • Rheumatology
  • Vascular Medicine

Background:

  • Giant cell arteritis (GCA) is an inflammatory condition affecting large arteries.
  • Acute cerebrovascular ischemic events, including stroke, are rare but severe complications of GCA.

Purpose of the Study:

  • To determine the prevalence of GCA-related stroke.
  • To analyze overall survival and relapse-free survival in GCA patients with and without stroke.
  • To identify risk factors associated with stroke in GCA patients.

Main Methods:

  • A multicentric retrospective analysis of 129 patients diagnosed with GCA between September 2010 and October 2018.
  • Comparison of demographic and clinical characteristics between GCA patients with and without acute ischemic cerebrovascular events.
  • Survival analysis using log-rank tests to compare overall and relapse-free survival.

Main Results:

  • 18% (16) of GCA patients experienced an acute ischemic cerebrovascular event.
  • Patients with stroke were older and more frequently male compared to those without stroke.
  • Overall survival (4.4 vs. 221.7 months) and 3-year relapse-free survival (8.42 vs. 78.0 months) were significantly decreased in GCA patients with stroke.

Conclusions:

  • Ischemic stroke is a significant complication of GCA, associated with increased mortality and reduced relapse-free survival.
  • Older age and male sex are identified as risk factors for stroke in GCA patients.
  • GCA patients experiencing stroke require vigilant monitoring for disease recurrence and survival outcomes.

Keywords:
Giant cell arteritisOutcomeStrokeTreatment

More Related Videos

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke11:32

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke

Published on: January 3, 2025

1.6K
Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke09:00

Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke

Published on: February 10, 2023

1.7K

Related Concept Videos

Regulation of Stroke Volume01:27

Regulation of Stroke Volume

The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
5.1K
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
3.4K
Cardiac Output and Stroke Volume01:11

Cardiac Output and Stroke Volume

Cardiac output (CO) is an integral aspect of human physiology, reflecting the heart's efficiency and responsiveness to the body's needs. It represents the volume of blood that the left or right ventricle ejects into the aorta or pulmonary trunk each minute. The CO is calculated by multiplying the heart rate (HR)—the number of heartbeats per minute—by the stroke volume (SV)—the amount of blood pumped out with each heartbeat.
In an average resting adult male, the typical cardiac...
4.8K
Cardiac Output II: Effect of Stroke Volume on Cardiac Output01:22

Cardiac Output II: Effect of Stroke Volume on Cardiac Output

Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
3.3K
Case Studies01:22

Case Studies

There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.
13.5K
Imaging Studies I: Kidney, Ureter, and Bladder Studies01:28

Imaging Studies I: Kidney, Ureter, and Bladder Studies

Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
344