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Senolytics and senostatics as adjuvant tumour therapy
Susan Short1, Edward Fielder2, Satomi Miwa2
1Leeds Institute of Cancer and Pathology, Wellcome Trust Brenner Building, St James's University Hospital, Beckett St, Leeds LS9 7TF, UK.
Ebiomedicine
|February 10, 2019
Summary
Cell senescence drives aging and cancer side effects. Targeting senescent cells with senolytics may prevent frailty and improve survival in cancer survivors.
Area of Science:
- Gerontology
- Oncology
- Cellular Biology
Background:
- Cell senescence is a key factor in aging, frailty, and age-related diseases.
- Tumor cell senescence can aid cancer therapies but may lead to resistant, stem-like cells.
- Therapy-induced senescence can spread via bystander effects, causing systemic accumulation of senescent cells.
Purpose of the Study:
- To investigate the role of systemic senescent cell accumulation in cancer survivors' frailty and mortality.
- To explore senolytics as a second-line adjuvant cancer therapy.
- To evaluate senostatic interventions for preventing or reversing therapy-induced frailty.
Main Methods:
- Hypothesizing the link between persistent senescent cell accumulation and adverse outcomes in cancer survivors.
- Reviewing the development and proposed application of senolytics.
- Analyzing the potential of senostatic interventions, including dietary restriction mimetics.
Main Results:
- Senescent cells contribute to aging and can promote cancer recurrence.
- Senolytics offer a potential strategy for adjuvant cancer therapy and mitigating treatment side effects.
- Senostatic interventions may reduce senescent cell burden in vivo, acting as net senolytics.
Conclusions:
- Systemic accumulation of senescent cells may underlie frailty and mortality in cancer survivors.
- Senolytics and senostatic interventions hold promise for improving cancer patient outcomes and survivorship.
- Targeting senescence pathways presents a novel therapeutic avenue in both aging and oncology.
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