Related Experiment Video

Updated: Jan 29, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.8K

Circulating Hematopoietic Stem/Progenitor Cells are Associated with Coronary Stenoses in Patients with Coronary Heart

Fu-Li Zhu1, Ning Zhang2, Xiao-Juan Ma2

  • 1Department of Cardiology, Beijing LuHe Hospital, Capital Medical University, Beijing, China.

Scientific Reports
|February 10, 2019
PubMed

Insights

The frequency of circulating hematopoietic stem/progenitor cells (HSPCs) is higher in patients with coronary heart disease (CHD). Increased HSPC levels correlate with coronary stenosis severity in CHD patients.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Immunology

Background:

  • Atherosclerotic plaque inflammation originates from hematopoietic stem/progenitor cells (HSPCs).
  • The relationship between circulating HSPCs and coronary stenosis in coronary heart disease (CHD) remains unclear.

Purpose of the Study:

  • To investigate the association between circulating HSPCs frequency and coronary stenosis in patients with CHD.

Main Methods:

  • Coronary angiography and echocardiography were performed on 468 participants.
  • Flow cytometry quantified Lineage-CD38-CD45RA(dim)CD34+ HSPCs in peripheral blood.
  • CHD was defined as coronary stenosis ≥50%, with severity categorized by ≥70% stenosis.

Main Results:

  • Circulating HSPCs frequency was 1.8-fold higher in CHD patients compared to non-CHD participants (p=0.047).
  • HSPCs were the sole marker associated with mild versus severe coronary stenosis (OR 2.08, p=0.0009).
  • Left ventricular ejection fraction inversely correlated with HSPCs frequency and CRP in CHD patients.

Conclusions:

  • Circulating HSPCs frequency is closely related to coronary stenosis in CHD patients.
  • HSPCs may serve as a potential biomarker for assessing coronary stenosis severity.

More Related Videos

Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart08:22

Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart

Published on: April 15, 2020

19.6K
Analysis of Coronary Vessels in Cleared Embryonic Hearts08:25

Analysis of Coronary Vessels in Cleared Embryonic Hearts

Published on: December 7, 2016

8.6K

Related Concept Videos

Coronary Circulation01:21

Coronary Circulation

The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
7.2K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.1K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
426
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
267
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
368
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
684