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Updated: Jan 29, 2026

Assessment of Physical Activity Intensity with Accelerometers and Oxygen Consumption
Published on: June 20, 2025
Capsaicin supplementation increases time to exhaustion in high-intensity intermittent exercise without modifying
Marcelo Conrado de Freitas1,2, François Billaut3, Valéria Leme Gonçalves Panissa4
1Skeletal Muscle Assessment Laboratory (LABSIM), Department of Physical Education, School of Technology and Sciences, São Paulo State University (UNESP), Presidente Prudente, Brazil.
Purpose:
The purpose of this study was to investigate the acute effect of capsaicin supplementation on performance and physiological responses during high-intensity intermittent exercise (HIIE).
Method:
Thirteen physically active men (age = 24.4 ± 4.0 years; height = 176.4 ± 6.9 cm; body mass = 78.7 ± 13.8 kg; running training per week = 3.9 ± 0.9 h) performed an incremental running test to determine peak oxygen uptake ([Formula: see text]) and the speed associated with [Formula: see text] (s[Formula: see text]). Thereafter, subjects completed two randomized, double-blind HIIE (15s:15 s at 120% s[Formula: see text]) trials 45-min after consuming capsaicin (12 mg) or an isocaloric placebo. Time to exhaustion, blood lactate concentration, oxygen consumption during and 20 min post-exercise, energy expenditure, time spent above 90% of [Formula: see text], and the rate of perceived exertion were evaluated.
Results:
There was no difference between capsaicin and placebo for any variable except time to exhaustion [capsaicin: 1530 ± 515 s (102 efforts) vs placebo: 1342 ± 446 s (89 efforts); p < 0.001].
Conclusion:
In conclusion, capsaicin supplementation increased time to exhaustion in high-intensity intermittent exercise without modifying the metabolic response of exercise or the rate of perceived exertion in physically active men. Capsaicin could be used to increase the training load during specific exercise training sessions.
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