Related Experiment Video

Updated: Jan 29, 2026

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis
09:16

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis

Published on: June 18, 2020

7.3K

Distinction between MPO-ANCA and PR3-ANCA-associated glomerulonephritis in Chinese patients: a retrospective

Yan Hong1,2, Pengxian Shi1, Xia Liu3

  • 1Jinling Clinical Medical College of Nanjing Medical University, Nanjing, China.

Clinical Rheumatology
|February 10, 2019
PubMed
Abstract

Insights

MPO-ANCA is more common than PR3-ANCA in Chinese patients with ANCA-associated glomerulonephritis. These serotypes present with distinct clinical, histological, and outcome differences, suggesting they may represent separate disease entities.

Area of Science:

  • Nephrology
  • Immunology
  • Rheumatology

Background:

  • ANCA-associated glomerulonephritis (AAGN) is a severe autoimmune condition.
  • Distinguishing between MPO-ANCA and PR3-ANCA is crucial for understanding disease heterogeneity.

Purpose of the Study:

  • To compare clinical, histological, and outcome differences between MPO-ANCA and PR3-ANCA in AAGN patients.
  • To investigate if MPO-ANCA and PR3-ANCA represent distinct disease entities.

Main Methods:

  • Retrospective analysis of 467 AAGN patients.
  • Classification into MPO-AAGN and PR3-AAGN groups based on ANCA serotype.
  • Comparison of clinical, histological, and renal outcomes between groups.

Main Results:

  • MPO-ANCA (91.9%) was predominant over PR3-ANCA (8.1%).
  • MPO-AAGN patients were older, had a higher proportion of females, and showed less extra-renal involvement (joint, ENT, skin, eye) compared to PR3-AAGN.
  • MPO-AAGN had lower BVAS scores, higher serum albumin, less crescentic glomerulonephritis, and better relapse-free survival but similar renal survival rates compared to PR3-AAGN.

Conclusions:

  • MPO-ANCA is the dominant serotype in Chinese AAGN patients.
  • Significant differences in epidemiology, extra-renal manifestations, histopathology, and outcomes exist between MPO-ANCA and PR3-ANCA.
  • These findings support the classification of MPO-ANCA and PR3-ANCA as distinct disease entities.
Keywords:
Antineutrophil cytoplasmic antibodyGlomerulonephritisMyeloperoxidaseProteinase 3

More Related Videos

Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis06:05

Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis

Published on: January 27, 2023

28.0K
Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment05:58

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment

Published on: March 11, 2021

5.1K

Related Concept Videos

Patient-centered Care01:13

Patient-centered Care

Patient-centered care involves delivering care beyond inpatient hospitalization. Reflective practice can enhance a patient-centered approach. Reflective practice is a process of reasoning that considers all aspects of the present situation, including practicalities, learning from personal practice, and consideration of patient needs. Patients appreciate care decisions made while considering their input. Involving the patient in their care provides the patient with a sense of contribution rather...
3.0K
Lattice Centering and Coordination Number02:33

Lattice Centering and Coordination Number

The structure of a crystalline solid, whether a metal or not, is best described by considering its simplest repeating unit, which is referred to as its unit cell. The unit cell consists of lattice points that represent the locations of atoms or ions. The entire structure then consists of this unit cell repeating in three dimensions. The three different types of unit cells present in the cubic lattice are illustrated in Figure 1.
Types of Unit Cells
Imagine taking a large number of identical...
11.5K
Center of Gravity00:58

Center of Gravity

The center of gravity (COG) of an object is the point where the object's total weight is considered to be concentrated. Knowing the location of the center of gravity is useful when predicting the behavior of a moving object or designing static structures. In a uniform gravitational field, the center of gravity is similar to the center of mass (COM); yet, these two points can be positioned differently. For example, the Moon's center of mass lies very close to its geometric center, but...
6.7K
Center of Gravity01:15

Center of Gravity

The center of gravity is the point at which an object's weight appears to be concentrated and can be used to balance the object perfectly. This point is essential in mechanics as it provides information regarding a body's stability and moments of inertia. The center of gravity does not always have to fall within the shape or boundaries of the body; it may also lie outside the body in certain cases.
To determine its location, the principle of moments can be utilized by dividing the object into...
2.2K
Center of Mass00:59

Center of Mass

The center of mass is the point at which the total mass of an object can be said to be concentrated. It is a fundamental principle in mechanics and physics that applies to all objects regardless of their shape or size. The center of gravity is the point at which an object’s weight appears to be concentrated and can be used to balance the object perfectly.
The knowledge of the center of mass can also help us to describe and predict the motion of objects. For example, when a ball is thrown...
2.0K
Instantaneous Center of Zero Velocity01:20

Instantaneous Center of Zero Velocity

General plane motion, often observed in a rolling wheel, refers to a type of movement where the wheel is simultaneously rotating and translating. This complex motion can be understood by breaking it down into individual components.
To analyze this, consider two points on the wheel: point A and point B. The absolute velocity of point B can be expressed as the vector sum of the absolute velocity of point A and the relative velocity of point B with respect to point A. To simplify this analysis,...
832