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Updated: Jan 29, 2026
10:08
Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis
Published on: August 12, 2019
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L-Thyroxine induces thermotolerance in yeast.
Konstantinos Papamichael1,2, Basil Delitheos3, Iordanis Mourouzis3
1Department of Pharmacology, Medical School, National and Kapodistrian University of Athens, M. Asias 75, GR-11527, Athens, Greece. kpapamdoc@yahoo.gr.
Cell Stress & Chaperones
|February 10, 2019
Summary
Long-term exposure to L-thyroxine (T4) enhances yeast thermotolerance. This cellular stress response is dose-dependent and linked to Hsp90 and H+ trafficking.
Area of Science:
- Cellular biology
- Yeast genetics
- Endocrinology
Background:
- The cellular stress response (CSR) is a fundamental biological process.
- Heat shock (HS) is a common cellular stressor.
- Hormones can modulate cellular stress responses.
Purpose of the Study:
- To investigate the effect of L-thyroxine (T4) on the heat shock response in Saccharomyces cerevisiae.
- To determine if T4 influences yeast thermotolerance.
Main Methods:
- Yeast cultures (Saccharomyces cerevisiae) were exposed to L-thyroxine (T4) long-term.
- Cellular stress response was evaluated by assessing growth and viability after heat shock (53°C for 30 min).
Main Results:
- Long-term T4 exposure induced a dose-dependent thermotolerance in yeast.
- The observed thermotolerance was related to Hsp90 and H+ trafficking.
Conclusions:
- L-thyroxine (T4) plays a role in modulating the yeast heat shock response.
- T4 can enhance cellular thermotolerance through mechanisms involving Hsp90 and H+ trafficking.
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