Related Experiment Video
Updated: Jan 29, 2026
Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
Published on: April 29, 2010
Reply
Agustín Albillos1,2,3, Leticia Muñoz2,3, Melchor Álvarez-Mon2,3,4
1Hospital Ramón y Cajal, IRYCIS, Madrid, Spain.
Abstract:
We read with interest the letter by P Dey regarding our article which addresses the role of microbiome in driving intestinal inflammation, barrier disruption and bacterial translocation in CCl4 -cirrhosis (1). P Dey claims that dysbiosis and inflammation in this model can be attributed, rather than to cirrhosis, to the effects of CCl4 on the gut microbiome, and that the resultant dysbiosis becomes the major driver of CCl4 -liver damage. This article is protected by copyright. All rights reserved.
Insights
The gut microbiome plays a crucial role in liver damage, intestinal inflammation, and barrier disruption. Carbon tetrachloride-induced cirrhosis highlights the microbiome's impact on liver disease progression.
Area of Science:
- Gastroenterology and Hepatology
- Microbiology
- Immunology
Background:
- Carbon tetrachloride (CCl4) administration is a common method for inducing liver cirrhosis in animal models.
- The gut microbiome's role in liver disease, including cirrhosis, is increasingly recognized.
- Previous research has suggested a link between gut dysbiosis and the progression of liver damage.
