The development of monoaminergic neurotransmitter systems in childhood and adolescence

Brain maturation extends throughout adolescence well into early adulthood. Knowledge on developmental changes is crucial for age-appropriate pharmacotherapy. This article reviews data on maturational processes with a focus on the noradrenergic, dopaminergic, and serotonergic neurotransmitter systems.The literature was searched with a focus on studies in humans. However, since data in humans are limited animal studies were also included. All reviewed neurotransmitter systems show age-related development processes that differentiate child and adolescent brain function from those of adult brains. Unfortunately, the state of knowledge surrounding development-related changes remains sufficiently sparse, There is a high need for more studies on pediatric psychopharmacology and its biological underpinnings. Safety and efficacy of psychopharmacological medicines cannot be readily extrapolated from adults.