Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypersensitivities01:30

Hypersensitivities

7.4K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
7.4K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

623
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
623
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

958
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
958
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

1.0K
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
1.0K
Restless Leg Syndrome and Night Terrors01:27

Restless Leg Syndrome and Night Terrors

549
Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
549
Acute Coronary Syndrome V: Nursing Management01:26

Acute Coronary Syndrome V: Nursing Management

324
Nursing Assessment:Nursing management of acute coronary syndrome (ACS) involves taking the patient's history, focusing on primary complaints such as chest pain, dyspnea, and excessive sweating (diaphoresis), as well as other symptoms like back or jaw pain, nausea, vomiting, palpitations, dizziness, and fatigue. The nurse also reviews the patient's history of cardiac events, risk factors such as hypertension, diabetes, smoking, family history, and current medications.In the objective assessment,...
324

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improving identification of SJS/TEN and its mimics across a large geographic area: Outcomes from a novel telemedicine collaboration.

Journal of the American Academy of Dermatology·2025
Same author

American College of Rheumatology Guidance Statement for Diagnosis and Management of VEXAS Developed by the International VEXAS Working Group Expert Panel.

Arthritis & rheumatology (Hoboken, N.J.)·2025
Same author

Correction to: Mastocytosis in the Skin: Approach to Diagnosis, Evaluation, and Management in Adult and Pediatric Patients.

American journal of clinical dermatology·2025
Same author

Mastocytosis in the Skin: Approach to Diagnosis, Evaluation, and Management in Adult and Pediatric Patients.

American journal of clinical dermatology·2025
Same author

Immunotherapy-associated lichen planus pemphigoides successfully treated with intravenous immune globulin-Two illustrative cases.

JAAD case reports·2024
Same author

Case Report: Multidisciplinary management of a patient with indolent systemic mastocytosis and refractory symptoms.

Frontiers in allergy·2024

Related Experiment Video

Updated: Jan 29, 2026

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
10:22

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

34.1K

Vancomycin-associated drug-induced hypersensitivity syndrome.

Lauren M Madigan1, Lindy P Fox2

  • 1Department of Dermatology, University of Utah, Salt Lake City, Utah.

Journal of the American Academy of Dermatology
|February 10, 2019
PubMed
Summary

Vancomycin-associated drug-induced hypersensitivity syndrome (DIHS) presents uniquely with significant kidney involvement. This study defines the clinical features of vancomycin-induced DIHS, highlighting increased renal dysfunction compared to other causes.

Keywords:
DIHSDRESSdrug reaction with eosinophilia and systemic symptomsdrug-induced hypersensitivity syndromerenal dysfunctionvancomycin

More Related Videos

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome
04:49

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome

Published on: July 5, 2024

1.8K
Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

16.7K

Related Experiment Videos

Last Updated: Jan 29, 2026

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
10:22

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

Published on: September 16, 2011

34.1K
Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome
04:49

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome

Published on: July 5, 2024

1.8K
Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

16.7K

Area of Science:

  • Pharmacology
  • Nephrology
  • Immunology

Background:

  • Drug-induced hypersensitivity syndrome (DIHS), also known as drug reaction with eosinophilia and systemic symptoms (DRESS), is a severe adverse drug reaction.
  • The specific clinical presentation of vancomycin-induced DIHS remains poorly defined.

Purpose of the Study:

  • To characterize the clinical phenotype of vancomycin-associated DIHS.
  • To investigate the incidence and severity of renal involvement in vancomycin-induced DIHS.

Main Methods:

  • Retrospective case series of 29 DIHS/DRESS cases over 8 years.
  • Literature review identifying 28 additional vancomycin-induced DIHS cases.
  • Analysis of vancomycin-associated acute interstitial nephritis for systemic hypersensitivity cases.

Main Results:

  • Vancomycin-induced DIHS cases exhibited a significantly higher incidence of renal dysfunction (75% in series, 68% in literature) compared to overall DIHS (10%-40%).
  • Retrospective series showed a greater degree of renal impairment in vancomycin-induced cases (median 4.98-fold creatinine increase) versus non-vancomycin cases (2.25-fold).

Conclusions:

  • Vancomycin-induced DIHS presents with a distinct phenotype characterized by substantial renal involvement.
  • Limitations include small sample size, retrospective design, and lack of renal biopsies.