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Granulocyte death mediated by specific antibodies in intravenous immunoglobulin (IVIG)

Stefanie Graeter1, Hans-Uwe Simon2, Stephan von Gunten1

  • 1Institute of Pharmacology, University of Bern, Bern, Switzerland.

Pharmacological Research
|February 10, 2019
PubMed

Granulocytes are key effector cells of the innate immune system that cause substantial by-stander tissue damage in a broad range of inflammatory disorders. Specific antibodies with the potential to regulate granulocyte survival are present in polyclonal intravenous immunoglobulin (IVIG) preparations and may contribute to the anti-inflammatory effects of high-dose IVIG therapy. Here, we discuss idiosyncratic characteristics of antibodies to FAS and Siglecs contained in IVIG pertaining to granulocyte death regulation and highlight implications for research and clinical practice.

Keywords:
EosinophilsFASGranulocytesHigh-dose IVIGIVIGImmunomodulationIntravenous immunoglobulinNeutrophilsSiglec-8Siglec-9

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