Related Experiment Video
Updated: Jan 29, 2026

In utero and ex vivo Electroporation for Gene Expression in Mouse Retinal Ganglion Cells
Published on: September 24, 2009
Mitochondrial-related gene associated to obesity can be modulated by in utero hyperglycemic environment
Maruhen A D Silveira1, João Paulo C Marcondes2, Juliana R Lara1
1UNESP, São Paulo State University, Botucatu Medical School, Department of Pathology, Botucatu, São Paulo, Brazil.
Abstract:
We investigated whether mitochondrial-related genes and proteins are modulated by hyperglycemia promoted by gestational diabetes (GDM), thereby increasing neonate obesity predisposition. 19 healthy pregnant women, 16 pregnant women with GDM and their respective neonates were enrolled. Additionally, 19 obese and 19 eutrophic adults were recruited as a reference population. Umbilical cord, peripheral blood and placental (villous and decidua) tissues were collected to evaluate SOD2, PPAR-α and PPARGC-1β and their respective protein expressions. Data from the reference population confirmed that the three genes and proteins were overexpressed in blood cells of obese compared to eutrophic subjects. Only SOD2 was found upregulated in placental villous (fetal side) tissue of GDM women. Therefore, our findings showed an interaction between the hyperglycemic environment and SOD2 modulation, but also indicated that none of the three genes is useful as potential biomarkers for obesity development.
More Related Videos
07:35Author Spotlight: Investigating the Blood Glucose Homeostasis in Murine Brain Using a Cost-Effective Hyperglycemic And Hypoglycemic Clamp Technique
Published on: January 26, 2024
11:43A Screenable In Vivo Assay for Mitochondrial Modulators Using Transgenic Bioluminescent Caenorhabditis elegans
Published on: October 16, 2015
Related Concept Videos
Export of Mitochondrial and Chloroplast Genes
Gene-Environment Interactions
Animal Mitochondrial Genetics
Obesity
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes
Drug Dosing: Obese Patients