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Related Concept Videos

Translation01:31

Translation

156.3K
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
156.3K
Translation01:31

Translation

17.8K
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
17.8K
Initiation of Translation02:33

Initiation of Translation

39.0K
Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
39.0K
Termination of Translation01:44

Termination of Translation

27.7K
The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
27.7K
Accelerators01:17

Accelerators

287
Accelerators in concrete serve as admixtures to speed up the hardening process, enabling the concrete to achieve early strength faster. Although accelerators do not necessarily impact the time it takes concrete to set, they reduce this time in practice. A common accelerator is calcium chloride, which is particularly useful for hastening early strength development in cold weather or for rapid repair jobs that require quick heat generation after mixing.
The effectiveness of calcium chloride can...
287
Lytic Cycle of Bacteriophages01:30

Lytic Cycle of Bacteriophages

77.9K
Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the...
77.9K

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Related Experiment Video

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Setup and Execution of the Rapid Cycle Deliberate Practice Death Notification Curriculum
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Translation to Practice: Accelerating the Cycle of Innovation to Impact.

Jeff R Anderson1, Thomas D Y Chung2, Leon Clark3

  • 1Office of Translation to Practice, Mayo Clinic, Rochester, MN; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN.

Mayo Clinic Proceedings
|February 11, 2019
PubMed
Summary

The Office of Translation to Practice (OTP) accelerates the adoption of new drugs, biological agents, and medical devices into clinical practice. It fosters collaboration among scientists and physicians to advance patient care through translational science.

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Area of Science:

  • * Clinical and translational sciences
  • * Medical innovation and product development

Background:

  • * The Office of Translation to Practice (OTP) was established in 2015 at Mayo Clinic's Center for Clinical and Translational Sciences.
  • * Its mandate is to develop and manage novel tools and processes for accelerating the translation of products into practice.

Purpose of the Study:

  • * To present and discuss the best practices, innovations, and successes of the OTP.
  • * To highlight the OTP's role in facilitating the translation of drugs, biological agents, and medical devices into clinical practice.

Main Methods:

  • * Strategic alliances and active scientific and project management involvement.
  • * Collaboration between Mayo Clinic physicians, scientists, and internal/external partners.

Main Results:

  • * Creation of valuable services through strategic alliances and project management.
  • * Advancement of translational projects benefiting patients.

Conclusions:

  • * The OTP has successfully created valuable services and advanced translational projects.
  • * Continued efforts by the OTP aim to enhance physician and scientist collaboration for patient benefit.