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Oxidized LDL upregulates macrophage DPP4 expression via TLR4/TRIF/CD36 pathways

Xiaoquan Rao1, Shi Zhao2, Zachary Braunstein3

  • 1Cardiovascular Research Institute, Case Western Reserve University, Cleveland, OH, USA; Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, USA.

Ebiomedicine
|February 11, 2019
PubMed
Summary

Oxidized LDL upregulates dipeptidyl peptidase-IV (DPP4) on macrophages via CD36 and TLR4 signaling. This links glucose metabolism and atherosclerosis in obesity.

Keywords:
AtherosclerosisDipeptidyl peptidase IVInflammationObesityOxidized LDL

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