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Multimodal MRI evaluation of parkinsonian limbic pathologies
Ernest W Wang1, Guangwei Du1, Mechelle M Lewis2
1Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA, USA.
Neurobiology of Aging
|February 11, 2019
Summary
This study reveals distinct limbic system changes in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy using MRI. These findings highlight the importance of limbic structures in parkinsonian syndromes.
Area of Science:
- Neuroimaging
- Neurology
- Radiology
Background:
- Previous multimodal magnetic resonance imaging (MRI) studies on parkinsonian syndromes predominantly focused on motor-related basal ganglia.
- Limbic structures, crucial for non-motor symptoms, have been less explored in these conditions.
Purpose of the Study:
- To investigate MRI-based changes in limbic structures (amygdala, hippocampus, nucleus accumbens) across different parkinsonian syndromes.
- To compare these changes with healthy controls and assess their correlation with clinical symptoms.
Main Methods:
- Multimodal MRI including mean diffusivity (MD), fractional anisotropy, R2*, quantitative susceptibility mapping, and volumetric analysis.
- Inclusion of 35 Parkinson's disease, 16 multiple system atrophy (MSA-P), 17 progressive supranuclear palsy (PSP) patients, and 37 controls.
Main Results:
- Parkinson's disease (PD) showed reduced nucleus accumbens (NAc) volume.
- MSA-P exhibited increased NAc R2*.
- PSP demonstrated elevated amygdala and hippocampus MD, and reduced hippocampus fractional anisotropy.
- Limbic MD correlated with non-motor and daily living scores in parkinsonian subjects.
Conclusions:
- Limbic structural and microstructural alterations are evident in different parkinsonian syndromes.
- These limbic changes are associated with clinical non-motor manifestations.
- Future research on parkinsonian syndromes should incorporate limbic system assessments using MRI.
Keywords:
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