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The functional roles of exosomes-derived long non-coding RNA in human cancer

Feiyu Chen1, Ning Wang1, Hor-Yue Tan1

  • 1a School of Chinese Medicine, Li Ka Shing Faculty of Medicine , The University of Hong Kong , Hong Kong , China.

Cancer Biology & Therapy
|February 12, 2019
PubMed

Insights

Exosomal long non-coding RNAs (lncRNAs) show promise as cancer biomarkers. Understanding their role in tumor progression, immunity, and drug resistance is crucial for developing new cancer diagnostics and therapeutics.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Cancer remains a leading cause of death globally, with current treatments often hindered by late diagnosis and resistance.
  • Novel diagnostic and therapeutic strategies are needed for improved cancer patient outcomes.
  • Circulating long non-coding RNAs (lncRNAs) are increasingly recognized as key regulators of cancer.

Purpose of the Study:

  • To elaborate on the functional roles of exosomal lncRNAs in cancer.
  • To discuss their potential as diagnostic and prognostic biomarkers.
  • To explore their therapeutic implications in malignancies.

Main Methods:

  • Review and synthesis of current literature on exosomal lncRNAs in cancer.
  • Analysis of the role of lncRNAs within extracellular vesicles (EVs), particularly exosomes.
  • Discussion of exosomal lncRNA involvement in tumor progression, immunomodulation, and drug resistance.

Main Results:

  • Exosomal lncRNAs are implicated as mediators of cancer progression and intercellular communication.
  • Their differential expression in bodily fluids suggests potential as non-invasive biomarkers.
  • Exosomal lncRNAs play roles in regulating tumor microenvironment and treatment response.

Conclusions:

  • Exosomal lncRNAs are critical players in carcinogenesis and represent promising targets for cancer therapy.
  • Further research into exosomal lncRNAs can lead to advancements in early cancer detection and personalized medicine.
  • Understanding exosomal lncRNA functions is vital for developing novel strategies against cancer.
Keywords:
Cancerexosomal lncRNAsexosomelong non-coding RNAmicrovesicle

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