Related Experiment Video

Updated: Jan 29, 2026

Author Spotlight: Marmoset Research - Scope and Challenges
04:52

Author Spotlight: Marmoset Research - Scope and Challenges

Published on: June 9, 2023

2.6K

High acetylsalicylic acid dosing in infants after modified Blalock-Taussig shunt

Arun Saini1, Ashwini D Joshi2, Krista M Cowan2

  • 11Division of Pediatric CriticalCare Medicine,Department of Pediatrics,The University of Tennessee Health Science Center,Memphis,TN,USA.

Cardiology in the Young
|February 12, 2019
PubMed

Insights

High-dose aspirin did not reduce shunt complications in infants undergoing modified Blalock-Taussig procedures. Post-operative red blood cell transfusions may be a modifiable risk factor for adverse events.

Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Surgery
  • Pharmacology

Background:

  • Shunt-related adverse events are common in infants after modified Blalock-Taussig (mBT) palliation.
  • Acetylsalicylic acid (aspirin) prophylaxis is used, but resistance and sub-therapeutic levels occur in infants.
  • The efficacy of high-dose aspirin in preventing these events is unclear.

Purpose of the Study:

  • To evaluate if high-dose aspirin reduces shunt-related adverse events in infants post-mBT.
  • To identify risk factors for shunt-related adverse events in this population.

Main Methods:

  • Retrospective cohort study of infants (≤1 year) undergoing mBT with aspirin.
  • Groups: standard-dose aspirin (≤7 mg/kg/day) vs. high-dose aspirin (≥8 mg/kg/day).
  • Compared incidence of shunt interventions, thrombosis, and mortality.

Main Results:

  • No significant differences in shunt interventions, thrombosis, or mortality between standard and high-dose aspirin groups.
  • Single-ventricle morphology and prolonged post-operative red blood cell transfusion were associated with adverse events.
  • High-dose aspirin was not associated with a decrease in shunt-related adverse events.

Conclusions:

  • High-dose aspirin may not be sufficient to reduce shunt-related adverse events in infants post-mBT.
  • Post-operative red blood cell transfusion is a potential modifiable risk factor.
  • A randomized trial is necessary to determine optimal aspirin dosing.
Abstract

Keywords:
Modified Blalock–Taussig shuntacetylsalicylic acidaspirincyanotic congenital heart lesionred blood cell transfusionshunt interventionshunt thrombosissingle ventricular physiologytransfusion-related adverse events

More Related Videos

Electrophysiological Measurements and Analysis of Nociception in Human Infants09:18

Electrophysiological Measurements and Analysis of Nociception in Human Infants

Published on: December 20, 2011

17.7K
P50 Sensory Gating in Infants12:55

P50 Sensory Gating in Infants

Published on: December 26, 2013

9.6K

Related Concept Videos

Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
292
Shunt Admittances01:26

Shunt Admittances

Shunt admittances play a crucial role in the analysis of transmission lines, particularly for three-phase systems with neutral conductors. When a uniformly charged conductor is positioned above the Earth, it induces an equal but opposite charge on its surface. This interaction creates electric field lines between the conductor and the Earth.
To model this effect, the method of images is employed. This method involves replacing the Earth with an image conductor that mirrors the original...
498
Dose Size and Dosing Frequency: Determination Methods01:21

Dose Size and Dosing Frequency: Determination Methods

Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...
289
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
236
Rational Dosage Regimen: Maintenance Dose and Loading Dose01:24

Rational Dosage Regimen: Maintenance Dose and Loading Dose

A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
5.4K
Dose-Response Relationship: Overview01:03

Dose-Response Relationship: Overview

Agonists can bind with and activate receptors, resulting in the formation of drug-receptor complexes. Once formed, these complexes catalyze many biochemical processes at the cellular level and subsequently induce a pharmacologic response. The degree of response is directly proportional to the fraction of activated receptors, which in turn, depends on the concentration of the drug at the receptor site as well as the sensitivity of the receptor. An increase in the administered dose contributes to...
5.1K