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Updated: Jan 29, 2026
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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
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Sinonasal glomangiopericytoma: A clinicopathologic study.
Farres Obeidin1, Lawrence J Jennings1, Borislav A Alexiev1
1Department of Pathology, Northwestern University Feinberg School of Medicine, Northwestern Memorial Hospital, 251 East Huron St, Feinberg 7-342A, Chicago, IL, 60611, United States.
Pathology, Research and Practice
|February 12, 2019
Summary
Sinonasal glomangiopericytoma (SNGP) is a rare nasal tumor. Characterizing its histology and molecular profile aids in diagnosing challenging cases, distinguishing it from mimics using an extended immunohistochemical panel.
Area of Science:
- Pathology
- Oncology
- Head and Neck Surgery
Background:
- Sinonasal glomangiopericytoma (SNGP) is a rare neoplasm in the nasal cavity and sinuses.
- Diagnosis can be challenging due to potential mimics with similar histology.
Purpose of the Study:
- To characterize the histological and molecular features of SNGP.
- To identify diagnostic markers for challenging cases.
Main Methods:
- Retrospective analysis of six SNGP cases over 15 years.
- Histological examination and targeted sequencing.
- Immunohistochemical analysis including smooth muscle actin, cyclin D1, CD99, β-catenin, TLE1, STAT6, S100, and SOX10.
Main Results:
- SNGP presents as enhancing soft tissue masses on imaging.
- Histologically, tumors show spindle cells with a vascular network.
- All cases were positive for smooth muscle actin, cyclin D1, CD99, β-catenin, and TLE1.
- Recurrent CTNNB1 mutations were identified in all tested cases.
Conclusions:
- An extended immunohistochemical panel aids in SNGP diagnosis.
- Markers like β-catenin, cyclin D1, and TLE1 are crucial.
- Distinguishing SNGP from mimics can be achieved without molecular studies in many cases.
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